Bioactive Products
| A unique collection of 41 natural compounds used for Anti-diabetic research | ||
| Catalog No: | B544 | Anti-diabetic Compound Library Screening Details |
| Size: | 1mg/well * 41 Compounds 2mg/well * 41 Compounds | |
| Cat. No. | Information |
| CFN90163 | (+)-Catechin hydrate (+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
| CFN90192 | 1,2,3,4,6-O-Pentagalloylglucose 1,2,3,4,6-O-Pentagalloylglucose(PGG) has antimutagenic, anti-proliferative, anti-invasive,vasodilatory, anti-inflammatory, anti-parasitic, anti-HBV, and antioxidant activities. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. PGG dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling; it also has inhibition of inducible NO synthase and cyclooxygenase-2 activity. |
| CFN90430 | Kalopanaxsaponin H Kalopanaxsaponin H has antidiabetic activity. |
| CFN97839 | Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. |
| CFN97844 | Sulfuretin Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways. Sulfuretin may have a potential role for neuroprotection, possibly through inhibition of phosphorylation of MAPK, PI3K/Akt, and GSK-3β, which leads to mitochondrial protection, NF-κB modulations and subsequent suppression of apoptosis via ROS-dependent pathwaysand, may be used as a therapeutic agent for PD; it also may have therapeutic value in preventing or delaying the progression of rheumatoid arthritis.Sulfuretin has therapeutical effect on leukemia, due to its potent apoptotic activity through the extrinsic pathway driven by a Fas-mediated caspase-8-dependent pathway. |
