Toosendanin (TSN) was used as a digestive tract-parasiticide and agricultural insecticide in ancient China;TSN is a selective presynaptic blocker, a L-type Ca 2+ channel agonist and an effective antibotulismic agent, by interfering with neurotransmitter release through an initial facilitation followed by a subsequent depression. TSN has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-60 cells.
Isoalantolactone, an apoptosis inducer, possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. Isoalantolactone induces apoptosis, may be mediated through caspase-dependent apoptotic pathways, S phase arrest, inhibition of phosphorylation of PI3K/Akt, and downregulation of Bcr/Abl.
1. Arecoline hydrobromide is a hypotensive agent.
2. Arecoline hydrobromide is formerly used as a cholinergic agent.
3. Arecoline hydrobromide is purgative, vermifuge and taenifuge agents in veterinary medicine.