1. Atraric acid inhibits the invasiveness of LNCaP cells through extracellular matrix.
2. Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases.
1. alpha-Tomatine has fungitoxicity , it is far more toxic at a high pH than at a low pH, this suggests that the unprotonated alkaloid is the active form and that it acts by complexing with fungal sterols.
2. alpha-Tomatine is toxic to an endoparasite of a major lepidopterous pest of tomatoes, the parasite acquires the alkaloid from its host after the host ingests the alkaloid, this form of interaction creates a potential dilemma to controlling herbivorous pests through chemical antibiosis in plants.
3. alpha-Tomatine induces programmed cell death mediated by reactive oxygen species in the fungal pathogen Fusarium oxysporum via activating phosphotyrosine kinase and monomeric G-protein signaling pathways.
4. alpha-Tomatine induces apoptosis and inhibits NF-κB activation on prostate cancer cells, suggests that it may be beneficial for protection against prostate cancer development and progression.
5. alpha-Tomatine can inhibit the metastatic ability of A549 cells by reducing MMP-2, MMP-9, and u-PA activities through suppressing phosphoinositide 3-kinase/Akt (PI3K/Akt) or ERK1/2 signaling pathway and inhibition NF-kappaB or AP-1 binding activities, suggests that alpha-tomatine may be an anti-metastatic agent against human lung adenocarcinoma.
6.Tomatine has anti-inflammatory activity.