Eriodictyol has vasodilator, anti-inflammatory and antioxidant activities, it is an antagonist of the transient potential vanilloid 1 receptor (TRPV1) receptor. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance, it attenuates the degree of retinal inflammation and plasma lipid peroxidation preserving the blood-retinal barrier (BRB) in early diabetic rats. It may be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness inAtopic dermatitis.
1. Lithospermic acid has antioxidant effects, is a competitive inhibitor of xanthine oxidas (XO), can directly scavenge superoxide and inhibit superoxide production in vitro, and presents hypouricemic and anti-inflammatory actions in vivo.
2. Lithospermic acid has inhibitory effects on proliferation and migration of rat vascular smooth muscle cells.
3. Lithospermic acid derivatives can increase expression of serine palmitoyltransferase in human HaCaT cells.
4. Lithospermic acid possesses anti-HIV activity.
5. Treatment with lithospermic acid B has a preventive effect on the development of diabetic retinopathy in this animal model, probably because of its antioxidative effects and anti-inflammatory effects.
6. Lithospermic acid can attenuate 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways.
7. Lithospermic acid has hepatoprotective effects against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo.
8. Lithospermic acid can attenuate mesenteric ischemia reperfusion injury in rat intestines by increasing tissue SOD and GPx activities and decreasing MDA and MPO levels, also improves morphological alterations which occurred after periods of reperfusion.
1. Astragalin may be a potential agent in the treatment of osteoarthritis.
2. Astragalin can be effective in allaying ROS-promoted bronchial fibrosis through inhibiting autophagosome formation in airways.
3. Astragalin ameliorates oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling.
4. Astragalin exerts anti-inflammatory properties possibly via the inactivation of TLR4-mediated NF-κB and mitogen-activated protein kinases signaling pathways in LPS-stimulated mMECs.
5. Astragalin exerts anti-inflammatory properties in LPS-mediated mastitis, possibly through inhibiting inhibition of the NF-κB signaling pathway, which mediates the expression of pro-inflammatory cytokines.
1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders.
2. Isoquercitrin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease.
3. Isoquercitrin is an inhibitor of Wnt/β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway.
4. Isoquercitrin and quercetin have anti-inflammatory activity in experimental murine allergic asthma, they are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies.
5. Isoquercitrin has antihypertensive effect, it-induced hypotension in rats is an event dependent on the inhibition of angiotensin II generation by angiotensin converting enzyme (ACE).
6. Isoquercitrin inhibits carbachol and leukotriene D4 -induced contraction in guinea-pig airways, it may be highly useful in treatment of asthma.
1. Crocin can relax smooth muscles, has a great potential to be a candidate for the treatment of asthma.
2. Crocin can protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production.
3. Crocin improves toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta.
4. Crocin protects rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release.
5. Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
6. Crocin yields its hypolipidemic effect by inhibiting pancreatic lipase, leading to the malabsorption of fat and cholesterol.
7. Crocin protects the photoreceptors against blue light- or white light-mediated damage in a concentration-dependent manner with an EC50 of approximately 30 microM, crocin protects retinal photoreceptors against light-induced cell death.