Crotaline venoms produce various toxic effects, although these are most commonly treated with specific antivenoms. Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale.
1. Demethylwedelolactone has trypsin inhibitory effect.
2. Demethylwedelolactone exerts anti-invasive growth effect on breast cancer cells.