Bioactive Products
| A unique collection of 32 Antidepressant natural compounds | ||
| Catalog No: | B72a10 | Antidepressant Compound Library Screening Details |
| Size: | 1mg/well * 32 Compounds 2mg/well * 32 Compounds | |
| Cat. No. | Information |
| CFN90003 | Agomelatine Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). Agomelatine is a melatonin (MT) analogue with agonistic properties and has been proven to be effective for various types of depressive symptoms, agomelatine also has anticonvulsant activity. Agomelatine treatment could represent a novel useful approach to the clinical care of subjects with Chronic Fatigue Syndrome (CFS). Agomelatine administration protects liver cells from paracetamol-induced hepatotoxicity via antioxidant activity and reduced proinflammatory cytokines, such as TNF-α and IL-6. |
| CFN90043 | Dehydroepiandrosterone Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist. Dehydroepiandrosterone can treat symptoms, and signs of vulvovaginal atrophy along with libido in postmenopausal women. Dehydroepiandrosterone is a neuroactive hormone, it in co-operation with other hormones and transmitters significantly affects some aspects of human mood, and modifies some features of human emotions and behavior; it has been reported that its administration can increase feelings of well-being and is useful in ameliorating atypical depressive disorders, it has neuroprotective and antiglucocorticoid activity and modifies immune reactions. |
| CFN98742 | Naringenin Naringenin is a weak estrogen that also exhibits partial antiestrogenic activity in the female rat uterus and MCF-7 human breast cancer cells. Naringenin is also a agent for the treatment of hepatitis C virus (HCV) infection. Naringenin has hypocholesterolemic, antioxidant, free radical scavenger, anti-cancer, anti-inflammatory, neuroprotective, carbohydrate metabolism promoter, and immune system modulator properties. Naringenin possesses potent antidepressant-like property via the central serotonergic and noradrenergic systems. |
| CFN98756 | Kaempferitrin Kaempferitrin exerts immunostimulatory, antidepressant-like , antiosteoporotic , cytotoxic and antitumor effects, the general mechanisms include cell cycle arrest in G1 phase and apoptosis via intrinsic pathway in a caspase dependent pathway. Kaempferitrin is an acute lowering effect on blood glucose in diabetic rats and to stimulate the glucose uptake percentile, as efficiently as insulin in muscle from normal rats. |
| CFN98796 | Orcinol Orcinol glucoside is anxiolytic agent without sedative effect, it improves depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus. |
