Bioactive Products
| A unique collection of 73 Antihyperglycemic natural compounds for high throughput screening (HTS) and high content screening (HCS). | ||
| Catalog No: | B545 | Antihyperglycemic Compound Library Screening Details |
| Size: | 1mg/well * 73 Compounds 2mg/well * 73 Compounds | |
| Cat. No. | Information |
| CFN97560 | Leachianone A Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. Leachianone A exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2); leachianone A also possesses a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment, its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. |
| CFN90225 | Trigonelline Trigonelline (1-methylpyridinium-3-carboxylate), an alkaloid present in coffee and fenugreek seed, exhibits phytoestrogenic, anti-adipogenesis, and anticancer activities, it also can reduce early glucose and insulin responses. Trigonelline has inhibition of the Nrf2 transcription factor and PPAR-γ. |
| CFN90236 | 3'-Hydroxy Puerarin 3'-Hydroxy Puerarin may have anti-inflammatory and antioxidant activities, it shows marked ONOO−, NO·, total ROS scavenging activities, and weak ·O2− scavenging activity.3'-Hydroxy Puerarin also can improve the insulin resistance via up-regulating the expression of PPARγ in 3T3-L1 adipocytes. |
| CFN90238 | 3,4,5-Tricaffeoylquinic acid 3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease. 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways, the effect be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH. |
| CFN90256 | Geraniin Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, has anti-oxidant , and anti-hyperglycemic activities, with an IC50 of 43 μM. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Geraniin induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death. |
