Bioactive Products
| A unique collection of 73 Antihyperglycemic natural compounds for high throughput screening (HTS) and high content screening (HCS). | ||
| Catalog No: | B545 | Antihyperglycemic Compound Library Screening Details |
| Size: | 1mg/well * 73 Compounds 2mg/well * 73 Compounds | |
| Cat. No. | Information |
| CFN98493 | Jatrorrhizine Jatrorrhizine has neuroprotective, antioxidative, anti-inflammatory, antihypercholesterolemic, and anti-hyperglycemia effects.Jatrorrhizine is expected to be developed as a new gastric prokinetic drug, it is metabolized by human CYP1A2 and multiple UGT1A isoforms. It has inhibitory activities against the expression of inducible NO syntase (iNOS) and cyclooxygenase-2 (COX-2), and can improve the utilization and excretion of cholesterol by up-regulating the mRNA and protein expression of LDLR and CYP7A1. |
| CFN98620 | Isovitexin Isovitexin, a food phytochemical contained in dietary rice products, it exhibits in vivo α-glucosidase inhibition, it possesses antihyperglycemic, neuroprotective, anti-inflammatory and anti-oxidant activities. Isovitexin inhibited xanthine oxidase with an IC50 value of 15.2 microM, it may protect cells from oxidative stress. It inhibited JNK, MAPK and NF-κB and activated HO-1/Nrf2 pathways. |
| CFN98668 | 3-O-Acetyloleanolic acid 3-O-Acetyloleanolic acid exhibits anti-angiogenic effects, it inhibits proliferation, migration and tube formation of umbilical vein endothelial cells (HUVECs) in a dose-dependent manner; it can inhibit VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral squamous cell carcinoma animal model. 3-O-Acetyloleanolic acid has antihyperglycemic activity, it shows a significant decrease in the glucose level of STZ-induced diabetic rats. |
| CFN98685 | Corosolic acid Corosolic acid has antitumor, anti-inflammatory and hypoglycemic activities, it can ameliorate hypertension, abnormal lipid metabolism, and oxidative stress as well as the inflammatory state in SHR-cp rats; it can improve glucose metabolism by reducing insulin resistance, it inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. Corosolic acid can suppress the M2 polarization of macrophages and tumor cell proliferation by inhibiting both STAT3 and NF-κB activation, it also can enhance the antitumor effects of adriamycin and cisplatin in in vitro. |
| CFN98726 | Nobiletin Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities, it could be a potential protective agent for the prevention and treatment of restenosis after angioplasty. Nobiletin downregulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), suppressed cell viability through AKT pathways. |
