Bioactive Products
| A unique collection of 51 Antihypertensive natural compound library for Antihypertensive screening | ||
| Catalog No: | Bb138 | Antihypertensive Compound Library Screening Details |
| Size: | 1mg/well * 51 Compounds 2mg/well * 51 Compounds | |
| Cat. No. | Information |
| CFN98155 | Isocorynoxeine Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage, it exhibits a significant neuroprotective effect against glutamate-induced HT22 cell death at the maximum concentration. |
| CFN98174 | Fargesin Fargesin has anti-inflammatory, anti-cancer, antihypertensive , and anti-bone-resorbing effects, it is widely used in the treatment of managing rhinitis, inflammation, histamine, sinusitis, and headache. Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice by activating Akt and AMPK in WAT. It as a potential β1 adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. |
| CFN98521 | Protoveratrine A Protoveratrine A has anti-hypertensive action, it has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width. Protoveratrine A can increase K + uptake from frog skeletal muscle and cause this tissue to release more calcium (Ca ++ ). Protoveratrine A seems to involve at least in part an inhibition of dopaminergic neuron activity, it enhances the release of acetylcholine from the nerve terminals during the resting period and at low frequency of stimulation. |
| CFN98542 | Syrosingopine Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. Syrosingopine can sensitize cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound, thus, combining syrosingopine and codrugs is a promising therapeutic strategy for clinical application for the treatment of cancer.Syrosingopine also has hypotensive properties. |
| CFN98543 | Resibufogenin Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu, which exhibits the anti-proliferative effect against cancer cells through the degradation of cyclin D1 caused by the activation of GSK-3β. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system. Resibufogenin corrects hypertension in a rat model of human preeclampsia, it not only prevents the advent of hypertension and proteinuria, but also the development of intrauterine growth restriction. |
