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Bioactive Products
Antimalaric Compound Library
A unique collection of 32 Antimalaric natural compounds for antimalaric drug research
Catalog No: B81 Antimalaric Compound Library
Screening Details
Size: 1mg/well * 32 Compounds
2mg/well * 32 Compounds
Cat. No. Information
CFN96143 Pellitorine

Pellitorine is a potential larvicide with a specific target site and a lead molecule for the control of mosquito populations, it also shows antiprotozoal activity against Plasmodium falciparum (IC50 = 3.3 ug/mL). Pellitorine shows potent antiplatelet aggregation activity, it can suppress expression of inducible NO synthase and cyclooxygenase-2. Pellitorine also shows strong cytotoxic activities against HL60 and MCT-7 cell lines.
CFN93816 Homogentisic acid

Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana. Homogentisic acid shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation. A derivative of homogentisic acid which inhibits Pfnek-1 with an IC(50) around 1.8 muM, this product is moderately active in vitro against a FcB1 P. falciparum strain (IC(50) = 12 muM).
CFN93577 Cratoxylone

1. Cratoxylone exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with the IC₅₀ value belows 3 uM.
CFN94427 Vulpic acid

Vulpic acid has therapeutic and prophylactic potential to be antibacterial and antiplasmodial agents, it can inhibit one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for liver stage activity.
CFN96330 Scoulerine

Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. It shows antiplasmodial activity with IC(50) values of 5.4uM and 3.1uM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively.