Bioactive Products
| A unique collection of 32 Antimalaric natural compounds for antimalaric drug research | ||
| Catalog No: | B81 | Antimalaric Compound Library Screening Details |
| Size: | 1mg/well * 32 Compounds 2mg/well * 32 Compounds | |
| Cat. No. | Information |
| CFN98427 | 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced β-amyloid (Aβ) aggregation, it has multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD. 8-Deoxygartanin has antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. 8-Deoxygartanin has cytotoxic effect on human melanoma cells, it inhibits p65 activation with IC50 values of 11.3 microM, it is a potential candidate as anti-melanoma agents. |
| CFN98454 | Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis. |
| CFN98467 | 9-Hydroxycalabaxanthone 9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α-mangostin shows the synergistic antimalarial interaction in both clones. |
| CFN98548 | Pseudolycorine Pseudolycorine, primarily studied as a new antiviral agent , it also shows remarkable antileukemic activity; it can halt HeLa cell growth at 10-1 mM or lower concentrations, it at its growth inhibitory concentrations blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Pseudolycorine and haemanthamine show good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66 uM or lower. |
| CFN98609 | Dehydroabietinol Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). |
