Bioactive Products
| Cat. No. | Information |
| CFN90218 | Corynoxine Corynoxine is a natural autophagy enhancer, promotes the clearance of Alpha-synuclein via Akt/mTOR pathway, it can significantly inhibit the oxidative stress of PC12 cells. |
| CFN90395 | Olaquindox Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induces apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway, might be suppressed through p38 MAPK and ROS-JNK pathways; it induces autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK.Olaquindox has genotoxic activity. |
| CFN92097 | Gambogenic acid Gambogenic acid is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects, it can cause aberrant autophagy to induce cell death and may suggest the potential application of Gambogenic acid as a tool or viable drug in anticancer therapies.Gambogenic acid could inhibit the proliferation of melanoma B16 cells and induce their apoptosis within certain time and concentration ranges. Its mechanism in inducing the cell apoptosis may be related to PI3K/Akt/mTOR signaling pathways. |
| CFN97864 | Tephrosin Tephrosin has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2. It may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), DG is currently under clinical evaluation for targeting tumor cells. |
| CFN92406 | Alisol B Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis.Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis. |
