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  • Bioactive Products
    Cancer-chemoprevention Compound Library
    A unique collection of 39 Cancer-chemoprevention natural compounds
    Catalog No: B99 Cancer-chemoprevention Compound Library
    Screening Details
    Size: 1mg/well * 39 Compounds
    2mg/well * 39 Compounds
    Catalog No. Information
    CFN99054 Cycloart-25-ene-3,24-diol

    1. (24R)-Cycloart-25-ene-3beta,24-diol exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation, it may be an anti-tumor promoter.
    CFN99280 Limonin

    Limonin is a widely used dietary supplement, one of the most prevalent citrus limonoids, which has antioxidant, anti-inflammatory, anticancer and anti-human immunodeficiency virus(HIV)activity. It induced a down regulation of TLR-2 ,TLR-4,TNF-α, TNF-α/IL-10,NF-κB and caspase. It showed the potent inhibition of CYP3A4, with IC50 values of 6.20 μM (CYP3A4/testosterone) and 19.10 μM (CYP3A4/midazolam).
    CFN99384 Lutein

    1. Lutein and lycopene has chemopreventive activity, the possible mechanism is their antioxidant effects.
    2. Nutritional supplementation with lutein or lutein together with antioxidants, vitamins, and minerals, improves visual function and symptoms in atrophic age-related macular degeneration (ARMD).
    CFN99115 6,7-Dihydroxycoumarin

    6,7-Dihydroxycoumarin(Esculetin) has various biological and pharmaceutical properties including anti-edema, anti-inflammatory, anti-tumour, hepatoprotective, anti-osteoarthritis and anti-rheumatoid arthritis effects. It inhibits lipoxygenases (LOs), p42/44 MAPK activation, PI3-kinase activation, as well as NF-kappaB and AP-1 activation, it exhibits competitive inhibition against the oxidation of 3-(3,4-dihydroxyphenyl)- alanine by mushroom, the IC50 value of is 43 microM.
    CFN99438 Isocoronarin D

    1. Isocoronarin D shows the highest Hb F induction effect of 1.6-fold at 20 microM.
    2. Isocoronarin D can activate antioxidant response element (ARE) (EC50 57.6 ± 2.4 uM), it may have potential chemopreventive activity.
    3. Isocoronarin D is a main active ingredient for inducing death of the tested cancer cells, it possesses a wide anti-cancer capability.