1. Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, in the causation of severe arrhythmias leading to death.
2. Aconitine appears to exert a long-lasting cholinergic action which may be involved in the genesis of aconitine-induced atrial fibrillation.
1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease.
2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice.
3. The co-administration of beta-Asarone and l-dopa may contribute to the treatment of 6-OHDA-induced damage in rats by inhibiting autophagy activity.
4. Beta-Asarone exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory mediators through NF-κB signaling and the JNK pathways in activated microglial cells and might be developed as a promising candidate to treat various neuroinflammatory diseases.
1. Cinobufotalin induces growth inhibition and apoptosis in cultured HCC cells through ceramide production, may be investigated as a novel anti-HCC agent.
2. Cinobufotalin can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins are down-regulated through the transcriptional pathway, is an effective reversal agent for the multidrug resistance of tumors.
1. Rhodojaponin II correlates pretty well with cardiotoxicity.
1. Ranaconitine has cardiotoxicity.