1. Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, in the causation of severe arrhythmias leading to death.
2. Aconitine appears to exert a long-lasting cholinergic action which may be involved in the genesis of aconitine-induced atrial fibrillation.
1. beta-Asarone has neuroprotection, it can afford a beneficial inhibition on both mRNA and protein expression of Bad, Bax, and cleavage of caspases 9 in rat hippocampus following intrahippocampal injections of Abeta (1-42).
2. beta-Asarone has anthelmintic activity using contractility of Ascaridia galli., it shows potent activity with IC50 values of 75.4 +/- 61.8 ng/mL.
3. beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice.
4. beta-Asarone has anticoagulant effect in the mouse and the rat.
5. beta-Asarone can inhibit colon cancer formation in vivo and in vitro by inducing senescence, since beta-asarone induces lamin B1 expression.
6. beta Asarone can cause liver and cardiac damages, it also has reproductive toxicity, beta asarone administered at a dose of 50mg/kg b.wt. is capable enough in bringing about moderate amount of degenerative changes in rat testis and altered antioxidant status.
7. beta-Asarone exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory mediators through NF-κB signaling and the JNK pathways in activated microglial cells and might be developed as a promising candidate to treat various neuroinflammatory diseases.
1. Cinobufotalin induces growth inhibition and apoptosis in cultured HCC cells through ceramide production, may be investigated as a novel anti-HCC agent.
2. Cinobufotalin can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins are down-regulated through the transcriptional pathway, is an effective reversal agent for the multidrug resistance of tumors.
1. Rhodojaponin II correlates pretty well with cardiotoxicity.
1. Ranaconitine has cardiotoxicity.