1. Strictosamide may have important effects on inflammation and inflammatory pain.
2. Strictosamide is slightly toxic to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity.
3. Strictosamide has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.
4. Strictosamide possesses antibacterial and antiviral activities.
1. Gardneramine inhibits the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.
1. Mesuaxanthone A and mesuaxanthone B are two yellow pigments.
2. Mesuaxantbone A and mesuaxanthone B produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and ether anaerthesia in mice and rats; they also exhibit anti inflammatory activity both by intraperitoneal and oral routes in rats.
1. (S)-Reticuline elicits vasorelaxation probably due to the blockade of the L-type voltage-dependent Ca(2+) current in rat aorta.
1. DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo.