1. Strictosamide may have important effects on inflammation and inflammatory pain.
2. Strictosamide is slightly toxic to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity.
3. Strictosamide has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.
1. Gardneramine inhibits the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.
1. Mesuaxanthone A and mesuaxanthone B are two yellow pigments.
2. Mesuaxantbone A and mesuaxanthone B produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and ether anaerthesia in mice and rats; they also exhibit anti inflammatory activity both by intraperitoneal and oral routes in rats.
1. (S)-Reticuline elicits vasorelaxation probably due to the blockade of the L-type voltage-dependent Ca(2+) current in rat aorta.
1. DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo.