Bioactive Products
| A unique collection of 60 Toxicity natural compounds for screening | ||
| Catalog No: | Bb201 | Toxicity Compound Library Screening Details |
| Size: | 1mg/well * 60 Compounds 2mg/well * 60 Compounds | |
| Cat. No. | Information |
| CFN99160 | DL-Menthol DL-Menthol has short term toxicity in rats, it plays a role in the induction of surgical anesthesia in fishes, related at least in part to the activation of GABAA receptors, and of rapid movement possibly via cold nociceptors. |
| CFN99168 | Podophyllotoxin Podophyllotoxin(Podofilox ) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podophyllotoxin has antitumor and antiviral properties, but it also shows cytotoxicity for normal cells and hence side effects derived from its lack of selectivity against tumoral cells. |
| CFN99196 | Triptolide Triptolide has immunosuppressive, anti-inflammatory, and anti-cancer activities, it induces apoptosis in tumor cells by blocking NF-KB activation and sensitizing tumor cells for TNF-a induced programmed cell death, it inhibits TGF-β1-induced cell proliferation and migration of rat airway smooth muscle cells, by suppressing Smad signaling and NF-κB ,respectively. Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM. |
| CFN99199 | Mesaconitine Mesaconitine has antinociceptive activity, has inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices. It has antiinflammatory activity, it induced Ca2+ influx and activation of nitric-oxide synthase in endothelial cells and, thus, induced vasorelaxation in rat aorta. |
| CFN99200 | Hypaconitine Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism. It produced neuromuscular blockade by reducing the evoked quantal release, the mechanism of this effect was attributed mainly to blocking of the nerve compound action potential. |
