1. Cathinone generates oxidative stress hampered antioxidant enzymes, glutathione and lipid peroxidation.
2. Cathinone induces significant behavioral changes and CNS activation in the hamster by systemic administration .
3. Cathinone causes hormonal alterations probably via changes in hypothalamo-hypophyseo-adrenocortical and gonadal axes integrity.
1. Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America, it produces short-term euphoria.
2. Cocaine constricts blood vessels, dilates pupils, and increases body temperature, heart rate, and blood pressure.
3. Cocaine has a small number of accepted medical uses such as numbing and decreasing bleeding during nasal surgery.
4. Cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces Cocaine seeking.
5. Cocaine can cause headaches and gastrointestinal complications such as abdominal pain and nausea. Because cocaine tends to decrease appetite, chronic users can become malnourished as well.
1. 8-O-Acetylharpagide has anti-inflammatory activity.
2. 8-O-Acetylharpagide has antibacteria and antiviral activities.
3. 8-O-Acetylharpagide has a biological activity on isolated smooth muscle preparations from guinea pig.
1. Yohimbine may augment extinction learning without significant side effects.
2. Yohimbine as a therapeutic augmentation strategy for exposure therapy in social anxiety disorder.
3. Yohimbine can be used as antagonistic agents against medetomidine-induced diuresis in healthy cats.
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors.
(a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft.
(b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 .
(c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-7901 cells by inducing ERK signaling pathway.
2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.