Natural Products
Germacrone
| Catalog No. | CFN98133 |  |
| CAS No. | 6902-91-6 | |
| Molecular Weight: | 218.34 | |
| Molecular Formula | C15H22O | |
| DBs | [PubChem]:274952374 [ChEMBL]:80830 [PCIDB]:11728 |
Standard InChI:
InChI=1S/C15H22O/c1-11(2)14-9-8-12(3)6-5-7-13(4)10-15(14)16/h7-8H,5-6,9-10H2,1-4H3/b12-8+,13-7-
Biological Activity
Germacrone, a natural product isolated from Rhizoma curcuma, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. [1]
Germacrone moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM，and produces two oxidized metabolites and four glutathione conjugates. [2]
Germacrone has anti-tumor activity against liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone. [3]
Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung, it could as a therapeutic agent alone or in combination with other agents for the treatment of influenza virus infection. [4]
Product
References
[1] Zhong Z, Chen X, Tan W, et al. Eur J Pharmacol, 2011, 667(1-3):50-5.
[2] Pimkaew P, Küblbeck J, Petsalo A, et al. Toxicol In Vitro, 2013, 27(6):2005-12.
[3] Liu Y, Wang W, Fang B, et al. Eur J Pharmacol, 2012, 698(1-3):95-102.
[4] Liao Q, Qian Z, Liu R, et al. Antivir Res, 2013, 100(3):578-588.
[5] Tai C, Zhong Z, Zhang Q. Drug Standards of China, 2012,13(2):93-95.
Product Use Citation
