Luteolin-7-O-glucoside

Luteolin-7-O-glucoside and luteolin at concentrations lower than 20 muM, significantly suppresses the productions of nitric oxide and prostaglandin E-2 (PGE(2)) in bacterial lipopolysaccharide activated-mouse macrophage RAW264.7 cells without introducing cytotoxicity; the inhibitory effects were further attributed to the suppression of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression, and not reduced enzymatic activity.^[1]

Luteolin-7-O-glucoside from Ailanthus altissima has antiasthmatic activity through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model.^[2]

Luteolin-7-O-Glucoside can induce apoptosis by scavenging ROS and suppressing the expression of β-catenin in COLO 320 DM cells and effectively inhibit ACF development in DMH-induced experimental carcinogenesis, Hence it can be a potent anticancer drug for colon carcinogenesis.^[3]

Luteolin-7-O-glucoside and luteolin can inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells.^[4]

Luteolin-7-O-glucoside has anti-asthmatic activity, can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.^[5]