Natural Products
Asiatic acid
| Catalog No. | CFN98688 |  |
| CAS No. | 464-92-6 | |
| Molecular Weight: | 488.7 | |
| Molecular Formula | C30H48O5 | |
| DBs | [PubChem]:255345075 [ChEMBL]:2873 [PCIDB]:3739 |
Standard InChI:
InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
Biological Activity
Asiatic acid is a pentacyclic triterpene contained in medicinal plants, can be used as an agent for increasing sensitivity of colon cancer cells to treatment with CPT-11 or as an agent for reducing adverse effects of CPT-11.[1]
Asiatic acid has been reported to induce apoptosis of various human cancer cells, it may exert anti-tumorigenesis through inhibitory actions in NO and COX-2 signals.[2]
Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation, its potential usage in the treatment of inflammatory bowel disease.[3]
Asiatic acid shows antidiabetic and antihyperlipidemic activity in diabetic rats.[4]
Asiatic acid (AA) has anti-inflammatory and antioxidant effects, it inhibits LPS-induced ALI in mice by inhibiting inflammatory cytokine production, which is mediated via blocking of the TLR4/NF-kB signaling pathway.[5]
Asiatic acid can inhibit cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells.[6]
Product
References
[1] Bunpo P, Kataoka K, Arimochi H, et al. J Med Invest, 2005, 52(1-2):65-73.
[2]Park B C, Paek S H, Lee Y S, et al. Biol Pharm Bul, 2007, 30(1):176-9.
[3] Guo W, Liu W, Jin B, et al. Int Immunopharmacol, 2015, 24(2):232-8.
[4] Ramachandran V, Saravanan R, Senthilraja P. Phytomed IntJ Phytothery Phytopharmacol, 2014, 21(3):225-32.
[5] Zhiling Li, Xianzhong Xiao, Mingshi Yang. Inflammation, 2016:1-7.
[6] Zhang J, Ai L, Lv T, et al. Oncol Lett, 2013, 6(6):1762-6.
[7] Tiwari R K, Chanda S, Deepak M, et al. J Chem Pharm Res, 2010(3):223-9.
Product Use Citation
