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Natural Products

Ellagic acid

Catalog No. CFN98716
CAS No. 476-66-4
Molecular Weight: 302.2
Molecular Formula C14H6O8
DBs [PubChem]:274951788
[ChEMBL]:4775
[PCIDB]:11153

Standard InChI:

InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

Biological Activity

Ellagic acid, a naturally occurring plant phenol, inhibits the activity of the direct-acting mutagen N-methyl-N-nitrosourea (MeNU) in Salmonella typhimurium TA100, is due to specific inhibition of methylation at the O6 position of guanine through an ellagic acid-duplex DNA affinity-binding mechanism.[1]
Ellagic acid has anti-oxidant and anti-inflammatory properties, can inhibit key cell functions and activation of PSCs, including platelet-derived growth factor (PDGF)-BB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, alpha-smooth muscle actin and collagen genes. [2]
Ellagic acid has antioxidant and apoptosis-inducing activities, shows high DPPH radical scavenging and peroxidation inhibition activities, significantly reduces HOS cell proliferation, and induces apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance.[3]

Product

Official website: Ellagic acid
Japanese website: Ellagic acid
Chinese website: Ellagic acid

References

[1] Dixit R, Gold B. P Natl Acad Sci USA, 1986, 83(21):8039-43.
[2] Masamune A, Satoh M, Kikuta K, et al. Biochem Pharmacol, 2005, 70(6):869-78.
[3] Han D H, Lee M J, Kim J H. Anticancer Res, 2006, 26(5A):3601-6.
[4] Ou L M, Seken A, Li K A, et al. Int J Pharm Res, 2015, 42(05):637-41.

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