Natural Products
20-Hydroxyecdysone
| Catalog No. | CFN98873 |  |
| CAS No. | 5289-74-7 | |
| Molecular Weight: | 480.6 | |
| Molecular Formula | C27H44O7 | |
| DBs | [PubChem]:274951632 [ChEMBL]:16587 [PCIDB]:3654 |
Standard InChI:
InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1
Biological Activity
20-hydroxyecdysone slowly reduces food consumption and then indirectly induces a state of starvation resulting in the elevation of the mRNA levels of InR , IRS , PI3K110 , and PDK in the Bombyx fat body during molting and pupation, and 20-hydroxyecdysone inhibits innate immunity in the fat body during Bombyx postembryonic development.[1,2]
20-hydroxyecdysone acts as both a positive and a negative regulator of EDG transcription, sequences in the promoter regions of two of the EDGs are similar to an ecdysone response element and may play a role in negative regulation.[3]
20-hydroxyecdysone can block TORC1 activity for autophagosome initiation, and upregulates Atg genes to induce autophagy in the Bombyx fat body.[4]
Product
Official website: 20-Hydroxyecdysone
Japanese website: 20-Hydroxyecdysone
Chinese website: 20-Hydroxyecdysone
Japanese website: 20-Hydroxyecdysone
Chinese website: 20-Hydroxyecdysone
References
[1] Ling T, Guo E, Diao Y, et al. Bmc Genomics, 2010, 11(1):1-12.
[2] Yan L, Zhou S, Li M, et al. J Insect Physiol, 2010, 56(10):1436-44.
[3] Apple R T, Fristrom J W. Dev Biol, 1991, 146(2):569-82.
[4] Tian L, Ma L, Guo E, et al. Autophagy, 2013, 9(8):1172-87.
[5] Kim J H, Kim J M, Kang D H. ResearchGate, 2008, 23(1).
Product Use Citation
