Natural Products
Schisandrol A
| Catalog No. | CFN99012 |  |
| CAS No. | 7432-28-2 | |
| Molecular Weight: | 432.5 | |
| Molecular Formula | C24H32O7 | |
| DBs | [PubChem]:274951495 [ChEMBL]: [PCIDB]:41495 |
Standard InChI:
InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3
Biological Activity
Schisandrin A and schisandrin B are active components of Schisandrae Fructus, has anti-inflammatory action, may act differentially on activating GST/ depleting cellular GSH and inducing an antioxidant response. [1]
Schisandrin A and Schisandrin B inhibit CYP3A activity by a mixed noncompetitive and complete inhibition, with IC(50) values of 6.60 and 5.51 microM and K(i) values of 5.83 and 4.24 microM, respectively.[2]
Schisandrin A is an MDR-reversing agent in chemotherapy for osteosarcoma, the mechanism is associated with reducing the IC50 of DOX , and increasing cleaved-PARP and cleaved-Caspase-7 levels in MG-63 cells transfected with the MDR1 expression vector.[3]
Schisandrin A and B induce OATP1B1 expression and increase its transporter activity in HepG2 cells..[4]
Schisandrin A, B, and C have certain protective effects on the oxidative damage of HaCat cells induced by H2O2. [5]
Product
References
[1] Kuan L P, Shan W H, Chen J, et al. Plos One, 2016, 11(5).
[2] Li W L, Xin H W, Su M W, et al. Method Find in Exp Clin, 2010, 32(3):163-9.
[3] Xia Y Z, Yang L, Wang Z D, et al. Rsc Adv, 2015, 5(18):13972-84.
[4] Guo C X, Deng S, Yin J Y, et al. Pharmazie, 2015, 70(1):29-32.
[5] Wei H. Journal of Anhui Agricultural Sciences, 2013, 41(3):1047-9.
[6] Xu XM, Li J P, Yan C, et al. Journal of Northeast Agricultural University, 2007, 14(4):323-6.
Product Use Citation
