Isoimperatorin

Isoimperatorin is a medicinal herbal product that is isolated from the dried roots of Angelicae dahuricae ,can inhibit the cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D 2 (PGD 2 ) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner, with IC 50 values of 10.7 μM and 24 μM, respectively; it may provide the basis for novel anti-inflammatory drugs.^[1]

Isoimperatorin possesses a potent hepatoprotective effect against AFB1, presumably through the induction of GSTalpha and the direct inhibition of CYP1A at 2 microM concentration , and suggests that it should be considered a potential chemopreventive.^[2]

Isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.^[3]

Isoimperatorin (IO) has antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294), IO has antimycobacterial activity against 2 drug-sensitive and 6 drug-resistant isolates, with minimum inhibitory concentrations (MICs) of 50-100 ug ml(-1) and 100-200 ug ml(-1), respectively; and IO exhibits synergistic antimycobacterial effects with rifampin (RMP), isoniazid (INH) and ethambutol (EMB) against 6 drug-resistant strains, with fractional inhibitory concentration index (FICI) values of 0.133–0.472, 0.123–0.475 and 0.124–0.25, respectively.^[4]