Natural Products
Saikosaponin B2
| Catalog No. | CFN99126 |  |
| CAS No. | 58316-41-9 | |
| Molecular Weight: | 780.98 | |
| Molecular Formula | C42H68O13 | |
| DBs | [PubChem]:274951292 [ChEMBL]: [PCIDB]: |
Standard InChI:
InChI=1S/C42H68O13/c1-21-29(47)34(55-35-32(50)31(49)30(48)24(18-43)53-35)33(51)36(52-21)54-28-11-12-38(4)25(39(28,5)19-44)10-13-40(6)26(38)9-8-22-23-16-37(2,3)14-15-42(23,20-45)27(46)17-41(22,40)7/h8-9,21,24-36,43-51H,10-20H2,1-7H3/t21-,24-,25-,26-,27-,28+,29+,30-,31+,32-,33-,34+,35+,36+,38+,39+,40-,41-,42-/m1/s1
Biological Activity
Saikosaponin B2(SSb2) is an efficient inhibitor of early entry, including neutralization of virus particles, preventing viral attachment, and inhibiting viral entry/fusion, SSb2 may be of value for development as an antagonist of entry and could be explored as prophylactic treatment during the course of liver transplantation.[1]
Saikosaponin B2 can induce differentiation and apoptosis in cultured b16 melanoma cell line: 347.[2]
Saikosaponin B2 induces apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity.[3]
Product
Official website: Saikosaponin B2
Japanese website: Saikosaponin B2
Chinese website: Saikosaponin B2
Japanese website: Saikosaponin B2
Chinese website: Saikosaponin B2
References
[1] Lin L T, Chung C Y, Hsu W C, et al. J Hepatol, 2015, 62(3):541–8.
[2] Zong Z P, Fujikawa-Yamamoto K, Tanino M, et al. Melanoma Res, 1997, 7(7).
[3] Zong Z P, Fujikawa-Yamamoto K, Tanino M, et al.Biochem Bioph Res Co, 1996, 219(2):480-5.
[4] Jun L I, Jiang H, Zhang Y P, et al.Chinese Pharm J, 2011, 46(1):61-3.
Product Use Citation
