Natural Products
Sweroside
| Catalog No. | CFN99455 |  |
| CAS No. | 14215-86-2 | |
| Molecular Weight: | 358.3 | |
| Molecular Formula | C16H22O9 | |
| DBs | [PubChem]:274950696 [ChEMBL]:80907 [PCIDB]:10794 |
Standard InChI:
InChI=1S/C16H22O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2,6-8,10-13,15-20H,1,3-5H2/t7-,8+,10?,11-,12?,13+,15+,16+/m1/s1
Biological Activity
Sweroside and swertiamarine are main constituents in Gentian (Gentiana lutea ssp. symphyandra), Gentian has wound healing activity, seems to be mainly due to the increase in the stimulation of collagen production and the mitotic activity by sweroside and swertiamarine , respectively; they also have cytoprotective effects, which may cause a synergism in terms of wound healing activity of Gentian. [1]
Sweroside has the anti-osteoporotic effect on the MG-63 cells and osteoblasts, it has a direct osteogenic effect on the proliferation and differentiation of cultured MG-63 cells and osteoblasts in vitro. [2]
Sweroside can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells, it may be an effective skin-whitening agent through the regulates the expression of MAP kinase and melanogenic enzymes. [3]
Sweroside and gentiopicroside suppress Pck1 expression and induce phosphorylation of components in the insulin signalling cascade, demonstrates that sweroside and gentiopicroside show insulin-mimicking effects on the regulation of Pck1 expression. [4]
Product
References
[1] Oztürk N, Korkmaz S, Oztürk Y, et al. Planta Med, 2006, 72(4):289-94.
[2] Sun H, Li L, Zhang A, et al. Fitoterapia, 2013, 84(1):174-9.
[3] Yong T J, Sang C J, Hwang J S, et al. Chem-biol interact, 2015, 238:33-9.
[4] Dr. Xianju Huang, Li J, Mr. ZhiYi Mei, et al. Biochem Cell Biol, 2016, 94(3): 270-8.
[5] Xin-Yu J I, Wang C, Liu B. Chinese J Exp Trad Med Formulae, 2014, 20(17):102-5.
Product Use Citation
