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Natural Products

Dammarenediol II

Catalog No. CFN99476
CAS No. 14351-29-2
Molecular Weight: 444.7
Molecular Formula C30H52O2
DBs [PubChem]:273016364
[ChEMBL]:62416
[PCIDB]:38920

Standard InChI:

InChI=1S/C30H52O2/c1-20(2)10-9-16-30(8,32)22-13-18-28(6)21(22)11-12-24-27(5)17-15-25(31)26(3,4)23(27)14-19-29(24,28)7/h10,21-25,31-32H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,27+,28-,29-,30+/m1/s1

Biological Activity

Dammarenediol-II synthase is a key rate-limiting enzyme during the process of rice synthesizes dammarane-type ginsenosides.[1]
Dammarenediol-II can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber formation and vascular endothelial-cadherin disruption, suggests that the natural drug dammarenediol-II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy.[2]
The medicinally important dammarenediol-II can be ectopically produced in tobacco, and the production of dammarenediol-II in tobacco plants allows them to adopt a viral defense system.[3]

Product

Official website: Dammarenediol II
Japanese website: Dammarenediol II
Chinese website: Dammarenediol II

References

[1] Huang Z, Lin J, Cheng Z, et al. Plant Sci, 2015, 239:106-14.
[2] Su-Hyeon Kim †, Se-Hui Jung †, Lee Y J, et al. Phytother Res, 2015, 29(12):1910–6.
[3] Lee M H, Han J Y, Kim H J, et al. Plant Cell Physiol, 2012, 53(1):173-82.
 

Product Use Citation