Thalictrum aquilegiifolium is a species of flowering plant in the Ranunculaceae (buttercup) family known by the common names greater meadow-rue, columbine meadow-rue, and French meadow-rue. Its native range extends through Europe and temperate Asia, with a naturalized distribution in North America limited to New York and Ontario.
Growing to 100 cm (39 in) tall by 45 cm (18 in) wide, it is an herbaceous perennial, with leaves composed of frilled leaflets resembling those of aquilegia. In early summer it bears clusters of fluffy pink flowers in flat-topped panicles.
Three cyanogenic constituents have been detected in Thalictrum aquilegifolium. The structures of two of these have been confirmed as p-glucosyloxymandelonitrile and p-glucosyloxymandelonitrile β-glucoside. These two compounds have been shown to be biosynthetically derived from tyrosine.