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Natural Products
Trichosanthes kirilowii

Trichosanthes kirilowii is a flowering plant in the family Cucurbitaceae found particularly in China. It is one of the 50 fundamental herbs used in traditional Chinese medicine. The plant is a source of the toxic anti-HIV type I ribosome-inactiving lectin trichosanthin.
It is  found that the anti-tumor components isolated from the extract of trichosanthes (EOT) are cucurbitacin D and dihydrocucurbitacin D, and suggest that cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
Trichosanthes kirilowii tuber is a traditional medicine which exhibits various medicinal effects including antidiabetic and anticancer activities in several cancer cells. Recently, it was reported that Cucurbitacin D (CuD) isolated from Trichosanthes kirilowii also induces apoptosis in several cancer cells. Constitutive signal transducer and activator of transcription 3 (STAT3), which is an oncogenic transcription factor, is often observed in many human malignant tumor, including breast cancer.

Trichosanthes kirilowii
Research products of Trichosanthes kirilowii
Catalog Product Name CAS Number Manual
CFN99716Palmitic acid57-10-3  PDF
CFN98748alpha-Spinasterol481-18-5  PDF
CFN99824alpha-Spinasterol glucoside1745-36-4  PDF
CFN98692alpha-Spinasterol acetate4651-46-1  n/a
CFN905763,29-Dibenzoyl karounitriol873001-54-8  PDF
CFN90563Karounidiol118117-31-0  PDF
CFN98713Daucosterol474-58-8  PDF
CFN99916Beta-Sitosterol83-46-5  PDF
CFN97326Stigmasterol83-48-7  PDF
CFN99769D-(+)-Glucose50-99-7  PDF
CFN99201Fumaric acid110-17-8  PDF
CFN99100Succinic acid110-15-6  PDF
CFN97000Uridine58-96-8  PDF
CFN98260Bryonolic acid24480-45-3  PDF
CFN99129Cucurbitacin B6199-67-3  PDF
CFN99642Rutin153-18-4  PDF
CFN98981Cosmosiin578-74-5  PDF
CFN98502Diosmetin-7-O-beta-D-glucopyranoside20126-59-4  PDF
CFN90210Diosmetin520-34-3  PDF
CFN98843Apigenin520-36-5  PDF
CFN98784Luteolin491-70-3  PDF
CFN98785Chrysoeriol491-71-4  PDF
CFN93021Chrysoeriol-7-O-glucoside19993-32-9  PDF
CFN99331Vanillic acid121-34-6  PDF
CFN90562Bryonolol39765-50-9  PDF
CFN97498Cucumegastigmane I929881-46-9  n/a
CFN99220Stigmastane-3,6-diol112244-29-8  PDF
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