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11-Hydroxy-12-methoxyabietatriene
11-Hydroxy-12-methoxyabietatriene
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 11-Hydroxy-12-methoxyabietatriene
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CAS No.: 16755-54-7
Catalog No.: CFN92286
Molecular Formula: C21H32O2
Molecular Weight: 316.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Cryst.
Source: The herbs of Salvia candidissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 11-Hydroxy-12-methoxyabietatriene is a natural product from Salvia candidissima.
In vitro:
J Agric Food Chem. 2005 Jun 29;53(13):5200-6.
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.[Pubmed: 15969497 ]

METHODS AND RESULTS:
The new diterpenes brussonol (1) and iguestol (6alpha,11-dihydroxy-12-methoxy-abieta-8,11,13-triene) (2) with an icetexane and a dehydroabietane skeleton, respectively, have been isolated from hairy root cultures of Salvia broussonetii. Other previously known diterpenes, 7-oxodehydroabietane, 11-Hydroxy-12-methoxyabietatriene, taxodione, inuroyleanol, ferruginol, deoxocarnosol 12-methyl ether, cryptojaponol, pisiferal, sugiol, isomanool, 14-deoxycoleon U, 6alpha-hydroxydemethylcryptojaponol, demethylsalvicanol, and demethylcryptojaponol, were also obtained from these roots. The insect antifeedant and toxic effects of several of these compounds were investigated against the insect pests Spodoptera littoralis and Leptinotarsa decemlineata. Additionally, their comparative cytotoxic effects were tested on insect Sf9 and mammalian CHO cells. Demethylsalvicanol (4) was a moderate antifeedant to L. decemlineata, whereas brussonol (1) was inactive. 14-Deoxycoleon U (15) was the strongest antifeedant, whereas demethylcryptojaponol (11) was toxic to this insect.
CONCLUSIONS:
None of these compounds had antifeedant or negative effects on S. littoralis ingestion or weight gains after oral administration. Demethylcryptojaponol (11) was cytotoxic to mammalian CHO and insect Sf9 cell lines, followed by the icetexane derivative brussonol (1), with moderate cytotoxicity in both cases. The remainder of the test compounds showed a strong selective cytotoxicty to insect Sf9 cells, with demethylsalvicanol (4) being the most active.
11-Hydroxy-12-methoxyabietatriene Description
Source: The herbs of Salvia candidissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1596 mL 15.7978 mL 31.5956 mL 63.1912 mL 78.9889 mL
5 mM 0.6319 mL 3.1596 mL 6.3191 mL 12.6382 mL 15.7978 mL
10 mM 0.316 mL 1.5798 mL 3.1596 mL 6.3191 mL 7.8989 mL
50 mM 0.0632 mL 0.316 mL 0.6319 mL 1.2638 mL 1.5798 mL
100 mM 0.0316 mL 0.158 mL 0.316 mL 0.6319 mL 0.7899 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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