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11-Hydroxytephrosin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 11-Hydroxytephrosin
Price:
CAS No.: 72458-85-6
Catalog No.: CFN97996
Molecular Formula: C23H22O8
Molecular Weight: 426.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Derris robusta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 11-Hydroxytephrosin inhibits NF-kappaB activity.
Targets: NF-kB | TNF-α
In vitro:
J Nat Prod. 2008 Oct;71(10):1696-700.
Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.[Pubmed: 18841906]
NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation.
METHODS AND RESULTS:
Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods.
CONCLUSIONS:
All compounds inhibited NF-kappaB activity, and tephrosin (1), 11-Hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 microM, respectively, in TNF-alpha-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-kappaB/DNA binding activity and suppressed the expression of NF-kappaB target genes.
11-Hydroxytephrosin Description
Source: The herbs of Derris robusta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3452 mL 11.7261 mL 23.4522 mL 46.9043 mL 58.6304 mL
5 mM 0.469 mL 2.3452 mL 4.6904 mL 9.3809 mL 11.7261 mL
10 mM 0.2345 mL 1.1726 mL 2.3452 mL 4.6904 mL 5.863 mL
50 mM 0.0469 mL 0.2345 mL 0.469 mL 0.9381 mL 1.1726 mL
100 mM 0.0235 mL 0.1173 mL 0.2345 mL 0.469 mL 0.5863 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Chebulagic acid

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CAS No: 23094-71-5
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Diosgenin

Catalog No: CFN99515
CAS No: 512-04-9
Price: $30/20mg
Rhoifolin

Catalog No: CFN99814
CAS No: 17306-46-6
Price: $50/20mg
8-Shogaol

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CAS No: 36700-45-5
Price: $368/20mg
Cryptotanshinone

Catalog No: CFN98478
CAS No: 35825-57-1
Price: $30/20mg
Maackiain

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CAS No: 19908-48-6
Price: $100/20mg
Daidzein

Catalog No: CFN98774
CAS No: 486-66-8
Price: $30/20mg
Fraxidin

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Price: $268/10mg
Epigoitrin

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Dihydroevocarpine

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