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14-Benzoylneoline
14-Benzoylneoline
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 14-Benzoylneoline
Price:
CAS No.: 99633-05-3
Catalog No.: CFN96225
Molecular Formula: C31H43NO7
Molecular Weight: 541.7 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Aconitum carmichaeli
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 14-Benzoylneoline is a natural product from Aconitum carmichaeli.
In vitro:
Anal Chem. 2014 May 20;86(10):4748-57.
Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli.[Pubmed: 24731167 ]
Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on specific diseases from complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no pathological tissue-derived CMC models that have ever been developed, as well as no visualized affinity comparison of potential active components between normal and pathological CMC columns.
METHODS AND RESULTS:
In this study, a novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional (2D) chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, as well as rapid screening of the specific therapeutic agents that counteract doxorubicin (DOX)-induced heart failure from Acontium carmichaeli (Fuzi). In total, 16 potential active alkaloid components with similar structures in Fuzi were retained on both normal and failing myocardium CMC models. Most of them had obvious decreases of affinities on failing myocardium CMC compared with normal CMC model except for four components, talatizamine (TALA), 14-acetyl-TALA, hetisine, and 14-Benzoylneoline. One compound TALA with the highest affinity was isolated for further in vitro pharmacodynamic validation and target identification to validate the screen results.
CONCLUSIONS:
Voltage-dependent K(+) channel was confirmed as a binding target of TALA and 14-acetyl-TALA with high affinities. The online high throughput comparative CMC analysis method is suitable for screening specific active components from herbal medicines by increasing the specificity of screened results and can also be applied to other biological chromatography models.
14-Benzoylneoline Description
Source: The roots of Aconitum carmichaeli
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.846 mL 9.2302 mL 18.4604 mL 36.9208 mL 46.151 mL
5 mM 0.3692 mL 1.846 mL 3.6921 mL 7.3842 mL 9.2302 mL
10 mM 0.1846 mL 0.923 mL 1.846 mL 3.6921 mL 4.6151 mL
50 mM 0.0369 mL 0.1846 mL 0.3692 mL 0.7384 mL 0.923 mL
100 mM 0.0185 mL 0.0923 mL 0.1846 mL 0.3692 mL 0.4615 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemical & pharmaceutical bulletin, 1985, 33(9), 3658-61.
Studies on the constituents of Aconitum species. III. On the components of Aconitum subcuneatum NAKAI.[Reference: WebLink]

METHODS AND RESULTS:
A new alkaloid, 14-Benzoylneoline, and four known alkaloids, neoline, karakoline, 14-acetyldelcosine, and penduline, were isolated from the roots of Aconitum subcuneatum NAKAI. The structures of 14-Benzoylneoline and penduline were confirmed by derivation of these compounds from neoline and aconitine, respectively.
CONCLUSIONS:
A radical-type deoxygenation of a bridgehead hydroxyl group at C-13 was used in the transformation of aconitine into penduline through three steps.
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