14-Deoxy-11-hydroxyandrographolide | CAS:160242-09-1

14-Deoxy-11-hydroxyandrographolide

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Product Name	14-Deoxy-11-hydroxyandrographolide
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CAS No.:	160242-09-1
Catalog No.:	CFN97815
Molecular Formula:	C₂₀H₃₀O₅
Molecular Weight:	350.45 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Description:

14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells.

In vitro:

Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1216-25.

Cell differentiation-inducing diterpenes from Andrographis paniculata Nees.[Pubmed: 8069972]

The methanol extract of the aerial part of Andrographis paniculata Nees showed potent cell differentiation-inducing activity on mouse myeloid leukemia (M1) cells.
METHODS AND RESULTS:
From the ethyl acetate-soluble fraction of the methanol extract, six new diterpenoids of ent-labdane type, 14-epi-andrographolide (3), isoandrographolide (4), 14-deoxy-12-methoxyandrographolide (7), 12-epi-14-deoxy-12-methoxyandrographolide (8), 14-deoxy-12-hydroxyandrographolide (9) and 14-Deoxy-11-hydroxyandrographolide (10) as well as two new diterpene glucosides, 14-deoxy-11,12-didehydroandrographi-side (12) and 6'-acetylneoandrographolide (14), and four new diterpene dimers, bis-andrograpolides A (15), B (16), C (17) and D (18), were isolated along with six known compounds. The structures of the diterpenoids were determined by means of spectral methods.
CONCLUSIONS:
Some of these compounds showed potent cell differentiation-inducing activity towards M1 cells.

14-Deoxy-11-hydroxyandrographolide Description

Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antileukaemic Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	57.0695 mL	71.3369 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	11.4139 mL	14.2674 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	5.7069 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.1414 mL	1.4267 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.5707 mL	0.7134 mL

CFN97600	Andropanolide	869807-57-8	350.45	C₂₀H₃₀O₅
CFN98923	Andrographolide	5508-58-7	350.5	C₂₀H₃₀O₅
CFN98666	14-Deoxy-11,12-didehydroandrographolide	42895-58-9	332.4	C₂₀H₂₈O₄
CFN99770	Dehydroandrographolide	134418-28-3	332.43	C₂₀H₂₈O₄
CFN92802	14-Deoxyandrographolide	4176-97-0	334.45	C₂₀H₃₀O₄
CFN90518	Deoxyandrographolide	79233-15-1	334.45	C₂₀H₃₀O₄
CFN97601	14-Deoxy-17-hydroxyandrographolide	869384-82-7	352.47	C₂₀H₃₂O₅
CFN97815	14-Deoxy-11-hydroxyandrographolide	160242-09-1	350.45	C₂₀H₃₀O₅
CFN97785	14-Deoxy-12-hydroxyandrographolide	219721-33-2	350.45	C₂₀H₃₀O₅
CFN96446	Vitexolide D	1788090-69-6	318.45	C₂₀H₃₀O₃