2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone | CAS:35241-54-4

2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone

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Description:

2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone can markedly augment TRAIL-induced apoptosis and cytotoxicity in LNCaP cells.

In vitro:

Molecules (Basel, Switzerland), 04 Aug 2010, 15(8):5336-5353.

Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells.[Reference: WebLink]

Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent. We examined the cytotoxic and apoptotic effect of chalcones and dihydrochalcones on TRAIL-mediated apoptosis in LNCaP prostate cancer cells.
METHODS AND RESULTS:
The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was detected using annexin V-FITC by flow cytometry and fluorescence microscopy. The DeltaPsim was evaluated using DePsipher staining by fluorescence microscopy.
CONCLUSIONS:
Our study showed that two tested chalcones (chalcone and 2',6'dihydroxy-4'-methoxychalcone) and three dihydrochalcones (2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone, 2',6'-dihydroxy-4'-methoxydihydro- chalcone, and 2',4',6'-trihydroxydihydrochalcone, called phloretin) markedly augmented TRAIL-induced apoptosis and cytotoxicity in LNCaP cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.

2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone Description

Source:	The herbs of Cedrus deodara
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone
Price:
CAS No.:	35241-54-4
Catalog No.:	CFN70345
Molecular Formula:	C₁₇H₁₈O₅
Molecular Weight:	302.3 g/mol
Purity:	>=98%
Type of Compound:	Chalcones
Physical Desc.:	Powder
Source:	The herbs of Cedrus deodara
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Chalcones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.308 mL	16.5399 mL	33.0797 mL	66.1594 mL	82.6993 mL
5 mM	0.6616 mL	3.308 mL	6.6159 mL	13.2319 mL	16.5399 mL
10 mM	0.3308 mL	1.654 mL	3.308 mL	6.6159 mL	8.2699 mL
50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.3232 mL	1.654 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.6616 mL	0.827 mL

CFN70304	2',6'-Dihydroxy-4,4'-dimethoxychalcone	20621-49-2	300.3	C₁₇H₁₆O₅
CFN96080	4-O-Methylhelichrysetin	56121-44-9	300.3	C₁₇H₁₆O₅
CFN97920	2'-O-Methylhelichrysetin	123316-64-3	300.3	C₁₇H₁₆O₅
CFN90741	Flavokawain C	56798-34-6	300.3	C₁₇H₁₆O₅
CFN98446	Flavokawain A	3420-72-2	314.3	C₁₈H₁₈O₅
CFN91683	2',4',6',4-Tetramethoxychalcone	94103-36-3	328.4	C₁₉H₂₀O₅
CFN99015	2',4'-Dihydroxy-2,3',6'-trimethoxychalcone	100079-39-8	330.3	C₁₈H₁₈O₆
CFN96084	3'-Methylflavokawin	1044743-35-2	314.3	C₁₈H₁₈O₅
CFN96164	3'-Methyl-4-O-methylhelichrysetin	109471-13-8	314.3	C₁₈H₁₈O₅
CFN70472	4,4'-Dimethoxychalcone	2373-89-9	268.3	C₁₇H₁₆O₃