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2. Pharmacological research
2-Hydroxy-3-methoxybenzoic acid glucose ester
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More articles cited ChemFaces products.
Mediators Inflamm.2016:7216912. Biomed Chromatogr. 2016 Mar 23.Acta Physiologiae PlantarumJanuary 2016, 38:7ScientificWorldJournal. 2014 Feb 9.Front Pharmacol. 2016 Nov 30
Advance Publication2015 Aug 18Mol Med Rep.2015 Sep 21Tumour Biol.2015 Jun 26J Agric Food Chem. 2017 Apr 5BMC Complement Altern Med.2017 Aug 9;
Oncology LettersJan. 25, 2018;Jour. of Stored Pro & Postharvest Res.March 2016Oncotarget. 2017 Jun 28;Evid Based Complement Alternat Med. 2017
Our products had been exported to the following research institutions and universities, And still growing.
University of Indonesia (Indonesia)Universidad Industrial de Santan... (Colombia)Almansora University (Egypt)Korea Intitute of Science and Te... (Korea)
Donald Danforth Plant Science Ce... (USA)John Innes Centre (United Kingdom)University of Illinois (USA)University of Liège (Belgium)
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||2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse. |
|Arch Pharm Res. 1998 Aug;21(4):436-9. |
|PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra.[Pubmed: 9875472]|
|In order to find out anti-platelet activating factor (PAF) from natural resources, Korean medicinal plants used for the treatments of peripheral circulation disorders were tested for their possible protective effects on PAF-induced anaphylactic shock.
METHODS AND RESULTS:
From the above screening, the methanol extract of Gentiana scabra showed a potent antagonistic activity against PAF. Water suspension of the extract was partitioned with CH2Cl2 and EtOAc, successively. The EtOAc fraction which showed the highest activity was chromatographed on silica gel to yield 6 fractions. From the fraction which showed higher PAF-antagonistic activity than the other fractions, compound 1 was isolated by recrystallization.
On the basis of spectral data, compound 1 was identified as 2-Hydroxy-3-methoxybenzoic acid glucose ester. The compound prevented the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
2-Hydroxy-3-methoxybenzoic acid glucose ester Description
||The whole plants of Gentiana scabra.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.