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2-Hydroxycinnamic acid
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Product Name 2-Hydroxycinnamic acid
Price: $30 / 20mg
CAS No.: 614-60-8
Catalog No.: CFN98193
Molecular Formula: C9H8O3
Molecular Weight: 164.16 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: White powder
Source: The herbs of Angraecum fragrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 2-Hydroxycinnamic acid has photooxidant activity; 2-hydroxycinnamic acid germanium has strong inhibitory effect on the tumor U14; trans-2-hydroxycinnamic acid has efficacy against trichlorfon-induced oxidative stress in wistar rats.
Targets: SOD | LPO
In vivo:
Toxicol Int. 2012 Sep;19(3):295-300.
Efficacy of trans-2-hydroxycinnamic Acid against trichlorfon-induced oxidative stress in wistar rats.[Pubmed: 23293469]
Trichlorfon is an organophosphate insecticide used to control cockroaches, crickets, silverfish, bedbugs, fleas, cattle grubs, flies, ticks, leaf miners, and leaf-hoppers. It is also used to treat domestic animals for control of internal parasites. Trans-2-Hydroxycinnamic acid (T2HCA) is a hydroxyl derivative of cinnamic acid. The present study highlights trichlorofon-induced toxicity and the protective role of T2HCA in the liver, kidney, and brain of female Wistar rats.
METHODS AND RESULTS:
The rats were given a single dose of trichlorofon (150 mg / kg bw) and pre- and post-treatment T2HCA (50 mg / kg bw) for seven days. Trichlorofon enhanced oxidative stress in liver, kidney, and brain of the rats, which was evident from the elevation of lipid peroxidation (LPO). The reduced level of non-enzymatic antioxidant glutathione (GSH) also indicated the presence of an oxidative insult. The activity of enzymatic antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx) was significantly decreased on trichlorfon administration. Pre and post treatment with T2HCA decreased the LPO level and increased SOD, CAT, GST, GR, GPx, and GSH in the brain, liver, and kidney. Trichlorfon-induced reduction in acelylcholinestrase was also ameliorated with T2HCA treatment.
CONCLUSIONS:
In conclusion, trichlorfon-mediated induction in the reactive oxygen species and disturbance in the antioxidant enzymes' defense system was moderately ameliorated by antioxidant trans-2-Hydroxycinnamic acid.
2-Hydroxycinnamic acid Description
Source: The herbs of Angraecum fragrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.0916 mL 30.4581 mL 60.9162 mL 121.8324 mL 152.2904 mL
5 mM 1.2183 mL 6.0916 mL 12.1832 mL 24.3665 mL 30.4581 mL
10 mM 0.6092 mL 3.0458 mL 6.0916 mL 12.1832 mL 15.229 mL
50 mM 0.1218 mL 0.6092 mL 1.2183 mL 2.4366 mL 3.0458 mL
100 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2183 mL 1.5229 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Northwest Pharmaceutical Journal, 2010, 25(6):438-9.
The inhibitory effect of 2-hydroxycinnamic acid germanium on the tumor U14.[Reference: WebLink]
To observe the inhibitory effect of 2-Hydroxycinnamic acid germanium on the tumor U14.
CONCLUSIONS:
The 2-Hydroxycinnamic acid germanium were administered to mice with high,middle and low dose for ten days constantly.The inhibitory effect of 2-Hydroxycinnamic acid germanium was calculated U14.Groups administered with high and middle dose were more effective and the group with low dose had a little inhibitory effect.
CONCLUSIONS:
The 2-Hydroxycinnamic acid germanium had strong inhibitory effect.
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