| In vitro: |
| Fitoterapia. 2003 Apr;74(3):308-11. | | Antimicrobial and cytotoxic constituents of Loranthus globosus.[Pubmed: 12727502] |
METHODS AND RESULTS:
(+)-Catechin, 3,4-Dimethoxycinnamyl alcohol and 3,4,5-trimethoxycinnamyl alcohol were isolated from the barks of Loranthus globosus.
CONCLUSIONS:
All compounds showed significant antimicrobial and cytotoxic activities. | | Indian J Exp Biol. 2010 Mar;48(3):314-7. | | Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.[Pubmed: 21046987] | Hexane, chloroform and ethyl acetate extracts (100 microg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani.
METHODS AND RESULTS:
Twelve compounds namely, methyleugenol (1), p-coumaryl diacetate (2), 1'-acetoxychavicol acetate (3), 1'-acetoxyeugenol acetate (4), trans-p-acetoxycinnamyl alcohol (5), trans-3,4-Dimethoxycinnamyl alcohol (6), p-hydroxybenzaldehyde (7), p-hydroxycinnamaldehyde (8), trans-p-coumaryl alcohol (9), galangin (10), trans-p-coumaric acid (11) and galanganol B (12) were isolated from these extracts.
CONCLUSIONS:
Of these, compounds 2, 3, 4 and 5 were found most active in vitro against promastigotes of L. donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 microM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga. |
|
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