|Phytochemistry Letters, 2011 ,4 (3) :328-332. |
|New lanostane-type triterpenoids, inonotsutriols D, and E, from Inonotus obliquus[Reference: WebLink]|
|Two new lanostane-type triterpenoids, inonotsutriols D ( 1) and E ( 2), were isolated from the sclerotia of Inonotus obliquus (Pers.: Fr.) Pil. (Japanese name: kabanoanatake; Russian name: chaga).
METHODS AND RESULTS:
Their structures were determined to be lanost-8-ene-3β,22 R,24 R-triol ( 1) and lanost-8-ene-3β,22 R,24 S-triol ( 2) on the basis of spectral data, including 2D NMR analysis. In addition, major compounds, inotodiol ( 3), trametenolic acid ( 4), 3beta-Hydroxylanosta-8,24-diene-21-al( 5), 21-hydroxylanosterol ( 6), inonotsuoxide A ( 7) and inonotsuoxide B ( 8) were identified, and all compounds, except 2, were evaluated for their cancer cell growth inhibitory activity against P388, HL-60, L1210 and KB cell lines.