Science | Nature | Cell | View More
Natural Products
4',6,7-Trimethoxyisoflavone
4',6,7-Trimethoxyisoflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 4',6,7-Trimethoxyisoflavone
Price: $30 / 20mg
CAS No.: 798-61-8
Catalog No.: CFN70489
Molecular Formula: C18H16O5
Molecular Weight: 312.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The rhizomes of Belamcanda chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $10.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Indian Institute of Science (India)
  • Heidelberg University (Germany)
  • Kitasato University (Japan)
  • Monash University (Australia)
  • Sanford Burnham Prebys Medical ... (USA)
  • Mahatma Gandhi University (India)
  • Universiti Malaysia Pahang (Malaysia)
  • Universite de Lille1 (France)
  • University of Madras (India)
  • Mendel University in Brno (Czech Republic)
  • University of Hull (United Kingdom)
  • More...
Package
Featured Products
Flavone

Catalog No: CFN70130
CAS No: 525-82-6
Price: $30/20mg
Peonidin chloride

Catalog No: CFN92034
CAS No: 134-01-0
Price: $380/5mg
Genipin

Catalog No: CFN99142
CAS No: 6902-77-8
Price: $40/20mg
1,3-Dicaffeoylquinic acid

Catalog No: CFN99123
CAS No: 30964-13-7
Price: $188/20mg
Sinapine

Catalog No: CFN00092
CAS No: 18696-26-9
Price: $88/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Resibufogenin

Catalog No: CFN98543
CAS No: 465-39-4
Price: $118/20mg
Neoschaftoside

Catalog No: CFN92071
CAS No: 61328-41-4
Price: $368/5mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.
Targets: MMP | ROS | NOX2 | ERK
4',6,7-Trimethoxyisoflavone Description
Source: The rhizomes of Belamcanda chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New compound 12 (Rhoifolin analog)

Catalog No: CFN95371
CAS No: N/A
Price: $318/5mg
ent-16beta,17-dihydroxy-9(11)-kaur...

Catalog No: CFN95172
CAS No: 55483-24-4
Price: $318/10mg
Platycodin J

Catalog No: CFN95395
CAS No: 1325614-80-9
Price: $318/5mg
Quercetin 3-O-beta-(6''-p-coumaroy...

Catalog No: CFN95088
CAS No: 143061-65-8
Price: $338/10mg
Gynosaponin TN2

Catalog No: CFN95331
CAS No: 77658-95-8
Price: $318/5mg
Tectoruside

Catalog No: CFN95051
CAS No: 38784-73-5
Price: $288/20mg
Ganoderic acid GS-1

Catalog No: CFN95571
CAS No: 1206781-64-7
Price: $413/5mg
Glicoricone

Catalog No: CFN95063
CAS No: 161099-37-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.202 mL 16.0102 mL 32.0205 mL 64.041 mL 80.0512 mL
5 mM 0.6404 mL 3.202 mL 6.4041 mL 12.8082 mL 16.0102 mL
10 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2808 mL 1.601 mL
100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Phytomedicine, 2014, 21(4):570-577.
Flavonoids promoting HaCaT migration: II. Molecular mechanism of 4',6,7-trimethoxyisoflavone via NOX2 activation.[Reference: WebLink]
Flavonoids are major active ingredients in plants and are considered components of food that provide medical or health benefits. They have diversified structures and have effects on human health, including wound healing induction. More than a hundred flavonoids were screened for HaCaT keratinocytes cellular migration measurements and the relationships between their structural properties and the effects promoting cellular migration were examined.
METHODS AND RESULTS:
Here, among flavonoids used in the previous structure-activity relationship calculations, 4',6,7-Trimethoxyisoflavone (TMF) was one of the compounds showing the best activity, so that its molecular mechanism of the wound healing effect on HaCaT keratinocytes was investigated in more detail. Our data revealed that TMF increased the wound healing rate, but not the proliferation rate, in a dose-dependent manner. Treatment of keratinocytes with TMF influenced signaling pathways, affecting the phosphorylation of AKT and ERK in a time-dependent manner. TMF also induced the cell-cell adhesion protein E-cadherin, which is essential for promoting collective cell migration. Furthermore, the TMF treatment group also showed higher ROS and NOX2 transcriptional and protein levels. Correlating with matrix metalloproteinase induction by TMF, levels of extracellular matrix proteins such as collagens I and III were significantly lower in the treatment group. To confirm that the effects of TMF occur through the NOX2 pathway, we co-treated cells with TMF plus an NADPH inhibitor (DPI) or a ROS scavenger (NAC). Western blotting revealed that DPI and NAC attenuated the effect of TMF, suggesting that TMF induces ROS through the NOX2 pathway and regulates keratinocyte migration.
CONCLUSIONS:
In summary, TMF promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.
Flavone

Catalog No: CFN70130
CAS No: 525-82-6
Price: $30/20mg
Peonidin chloride

Catalog No: CFN92034
CAS No: 134-01-0
Price: $380/5mg
Genipin

Catalog No: CFN99142
CAS No: 6902-77-8
Price: $40/20mg
1,3-Dicaffeoylquinic acid

Catalog No: CFN99123
CAS No: 30964-13-7
Price: $188/20mg
Sinapine

Catalog No: CFN00092
CAS No: 18696-26-9
Price: $88/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Resibufogenin

Catalog No: CFN98543
CAS No: 465-39-4
Price: $118/20mg
Neoschaftoside

Catalog No: CFN92071
CAS No: 61328-41-4
Price: $368/5mg
Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Tags: buy 4',6,7-Trimethoxyisoflavone | 4',6,7-Trimethoxyisoflavone supplier | purchase 4',6,7-Trimethoxyisoflavone | 4',6,7-Trimethoxyisoflavone cost | 4',6,7-Trimethoxyisoflavone manufacturer | order 4',6,7-Trimethoxyisoflavone | 4',6,7-Trimethoxyisoflavone distributor