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4-Hydroxyphenylacetonitrile
4-Hydroxyphenylacetonitrile
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 4-Hydroxyphenylacetonitrile
Price:
CAS No.: 14191-95-8
Catalog No.: CFN96596
Molecular Formula: C8H7NO
Molecular Weight: 133.15 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The leaves of Moringa oleifera lam., moringaceae.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 4-Hydroxyphenylacetonitrile shows strong antioxidative activity.
In vitro:
Nat Prod Res. 2004 Jun;18(3):231-9.
Antioxidants from rape (Brassica campestris vir. Japonica Hara) oil cake.[Pubmed: 15143833 ]

METHODS AND RESULTS:
A simple but novel compound, S-1-methoxy-1-(3,5-dimethoxy-4-hydroxyphenyl)ethane, was isolated as a moderately antioxidative compound from rape (Brassica campestris L. subsp. napus) oil cake together with 5 known compounds.
CONCLUSIONS:
Three of these compounds, indolacetonitrile, 4-hydroxyindolacetonitrile, and 4-Hydroxyphenylacetonitrile, showed strong antioxidative activity evaluated by the ferric thiocyanate method.
4-Hydroxyphenylacetonitrile Description
Source: The leaves of Moringa oleifera lam., moringaceae.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 7.5103 mL 37.5516 mL 75.1033 mL 150.2065 mL 187.7582 mL
5 mM 1.5021 mL 7.5103 mL 15.0207 mL 30.0413 mL 37.5516 mL
10 mM 0.751 mL 3.7552 mL 7.5103 mL 15.0207 mL 18.7758 mL
50 mM 0.1502 mL 0.751 mL 1.5021 mL 3.0041 mL 3.7552 mL
100 mM 0.0751 mL 0.3755 mL 0.751 mL 1.5021 mL 1.8776 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Revista Brasileira De Farmacognosia, 2009, 19(4):893-897.
Volatile and non-volatile chemical constituents of Moringa oleifera Lam., Moringaceae.[Reference: WebLink]
Phytochemical analysis of the ethanol extract from leaves of Moringa oleifera Lam., Moringaceae, yield the benzylnitriles: niazirine, niazirinine and 4-Hydroxyphenylacetonitrile, while of fruit shells only octacosane was isolated.
METHODS AND RESULTS:
The essential oils from leaves, flowers and fruits were examined by gas chromatography-mass spectrometry. The major constituents identified were: phytol (21.6%) and thymol (9.6%) in the leaves oil, octadecane (27.4%) and hexadecanoic acid (18.4%) in the flowers oil, docosane (32.7%) and tetracosane (24.0%) in the fruits oil.
CONCLUSIONS:
The structures of all compounds were identified by spectroscopic analyses (NMR, IR and MS). 4-Hydroxyphenylacetonitrile is reported for the first time to the Moringa genus and the essential oils of flowers and fruits are reported for the first time to the species M. oleifer.
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