Science | Nature | Cell | View More
Natural Products
4-O-Methylsappanol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 4-O-Methylsappanol
Price:
CAS No.: 104778-16-7
Catalog No.: CFN99068
Molecular Formula: C17H18O6
Molecular Weight: 318.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The heartwoods of Caesalpinia sappan
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Guangzhou Institutes of Biomedi... (China)
  • National Cancer Institute (USA)
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • Universite de Lille1 (France)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Korea Institute of Oriental Med... (Korea)
  • Universiti Sains Malaysia (Malaysia)
  • University of Beira Interior (Portugal)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Cancer Research Initatives Foun... (Malaysia)
  • Kyushu University (Japan)
  • More...
Package
Featured Products
Dioscin

Catalog No: CFN99516
CAS No: 19057-60-4
Price: $40/20mg
Demethylzeylasteral

Catalog No: CFN90136
CAS No: 107316-88-1
Price: $40/20mg
Platycodin D

Catalog No: CFN98134
CAS No: 58479-68-8
Price: $70/20mg
Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg
Zerumbone

Catalog No: CFN91066
CAS No: 471-05-6
Price: $70/20mg
Aerugidiol

Catalog No: CFN92621
CAS No: 116425-35-5
Price: $318/5mg
Ginsenoside Rh1

Catalog No: CFN99970
CAS No: 63223-86-9
Price: $60/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Dimethylacrylshikonin

Catalog No: CFN90164
CAS No: 24502-79-2
Price: $138/20mg
Dehydro-alpha-lapachone

Catalog No: CFN99641
CAS No: 15297-92-4
Price: $ /
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 4-O-Methylsappanol shows activity against this fungus against Beauveria bassiana.
Targets: Antifection
In vitro:
Biol Pharm Bull. 2009 May;32(5):945-9.
Cytoprotective constituents of the heartwood of Caesalpinia sappan on glutamate-induced oxidative damage in HT22 cells.[Pubmed: 19420770]

METHODS AND RESULTS:
The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-Methylsappanol (4), caesalpine J (5), pluchoic acid (6).
CONCLUSIONS:
At concentrations of 20-40 microM, compound 2 showed significant cytoprotective effects against glutamate-induced oxidative stress through the induction of heme oxygenase (HO)-1 in HT22-immortalized hippocampal cells. Compound 3 also showed moderate neuroprotective effect at 40 microM, but compounds 1, 4-6 did not show any protective effects against glutamate-induced cytotoxicity in HT22 cells.
4-O-Methylsappanol Description
Source: The heartwoods of Caesalpinia sappan
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
4'-Hydroxy-5,7,3'-trimethoxyflavon...

Catalog No: CFN95398
CAS No: 1239-68-5
Price: $318/5mg
Sativanone

Catalog No: CFN95388
CAS No: 70561-31-8
Price: $318/10mg
(Z)-Aldosecologanin (Centauroside)

Catalog No: CFN95079
CAS No: 82474-97-3
Price: $388/5mg
Methyl ganoderate F

Catalog No: CFN95584
CAS No: 98665-08-8
Price: $368/5mg
15-Methoxy-16-oxo-15,16H-strictic ...

Catalog No: CFN95261
CAS No: 1356388-38-9
Price: $368/5mg
Vaccarin E

Catalog No: CFN95252
CAS No: 2252345-81-4
Price: $318/10mg
Gardoside methyl ester

Catalog No: CFN95467
CAS No: 93930-20-2
Price: $318/10mg
Giganteone C

Catalog No: CFN95484
CAS No: 1071223-56-7
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1417 mL 15.7085 mL 31.4169 mL 62.8338 mL 78.5423 mL
5 mM 0.6283 mL 3.1417 mL 6.2834 mL 12.5668 mL 15.7085 mL
10 mM 0.3142 mL 1.5708 mL 3.1417 mL 6.2834 mL 7.8542 mL
50 mM 0.0628 mL 0.3142 mL 0.6283 mL 1.2567 mL 1.5708 mL
100 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.6283 mL 0.7854 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Fitoterapia. 2003 Sep;74(6):600-2.
Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana.[Pubmed: 12946725]

METHODS AND RESULTS:
Four homoisoflavonoids, 4-O-Methylsappanol (1), protosappanin A (2), brazilin (3) and caeasalpin J (4), isolated from Caesalpinia sappan, were tested for inhibitory activity against Beauveria bassiana.
CONCLUSIONS:
Compound 1 showed activity against this fungus.
Dioscin

Catalog No: CFN99516
CAS No: 19057-60-4
Price: $40/20mg
Demethylzeylasteral

Catalog No: CFN90136
CAS No: 107316-88-1
Price: $40/20mg
Platycodin D

Catalog No: CFN98134
CAS No: 58479-68-8
Price: $70/20mg
Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg
Zerumbone

Catalog No: CFN91066
CAS No: 471-05-6
Price: $70/20mg
Aerugidiol

Catalog No: CFN92621
CAS No: 116425-35-5
Price: $318/5mg
Ginsenoside Rh1

Catalog No: CFN99970
CAS No: 63223-86-9
Price: $60/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Dimethylacrylshikonin

Catalog No: CFN90164
CAS No: 24502-79-2
Price: $138/20mg
Dehydro-alpha-lapachone

Catalog No: CFN99641
CAS No: 15297-92-4
Price: $ /
Tags: buy 4-O-Methylsappanol | 4-O-Methylsappanol supplier | purchase 4-O-Methylsappanol | 4-O-Methylsappanol cost | 4-O-Methylsappanol manufacturer | order 4-O-Methylsappanol | 4-O-Methylsappanol distributor