Science | Nature | Cell | View More
Natural Products
5-Hydroxysophoranone
5-Hydroxysophoranone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 5-Hydroxysophoranone
Price:
CAS No.: 90686-12-7
Catalog No.: CFN96529
Molecular Formula: C30H36O5
Molecular Weight: 476.61 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The barks of Erythrina subumbrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Otago (New Zealand)
  • Worcester Polytechnic Institute (USA)
  • Universidade Federal de Santa C... (Brazil)
  • Lodz University of Technology (Poland)
  • Centralised Purchases Unit (CPU... (India)
  • Max-Planck-Insitut (Germany)
  • Universite de Lille1 (France)
  • Tohoku University (Japan)
  • Indian Institute of Science (India)
  • Universidade de Franca (Brazil)
  • University of Lodz (Poland)
  • More...
Package
Featured Products
Stevenleaf

Catalog No: CFN99189
CAS No: 80321-63-7
Price: $ / mg
Calceolarioside B

Catalog No: CFN90647
CAS No: 105471-98-5
Price: $238/20mg
Parishin C

Catalog No: CFN93114
CAS No: 174972-80-6
Price: $238/20mg
Integerrimine

Catalog No: CFN00419
CAS No: 480-79-5
Price: $ /
Purpurin

Catalog No: CFN92566
CAS No: 81-54-9
Price: $30/20mg
Cyanidin-3-O-(6''-malonylglucoside...

Catalog No: CFN91864
CAS No: 171828-62-9
Price: $613/5mg
Emodin

Catalog No: CFN98834
CAS No: 518-82-1
Price: $30/20mg
Hirsuteine

Catalog No: CFN90615
CAS No: 35467-43-7
Price: $268/5mg
Euphol

Catalog No: CFN89516
CAS No: 514-47-6
Price: $158/10mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 5-Hydroxysophoranone exhibits high antiplasmodial activity against Plasmodium falciparum (IC50=2.5 microg/mL).
Targets: Antifection
In vitro:
Arch Pharm Res. 2007 Nov;30(11):1398-403.
Biological activities of the chemical constituents of Erythrina stricta and Erythrina subumbrans.[Pubmed: 18087807]

METHODS AND RESULTS:
Phytochemical investigation of the hexane and CH2Cl2 extracts of Erythrina stricta roots and E. subumbrans stems led to the isolation of six pterocarpans, one flavanone, one isoflavone, two alkaloids, five triterpenes, six steroids and alkyl trans-ferulates. The structures of all known compounds were determined on the basis of spectroscopic evidence. Sophoradiol (15), a mixture of stigmast-4-en-3-one (19) and stigmasta-4,22-dien-3-one (20), lupeol (21), cycloeucalenol (22), a mixture of 3beta-hydroxystigmast-5-en-7-one (23) and 3beta-hydroxystigmast-5,22-dien-7-one (24) and melilotigenin C (25) were first isolated from the genus Erythrina. The isolated compounds were evaluated for antiplasmodial activity, antimycobacterial activity and cytotoxicity.
CONCLUSIONS:
Among the tested compounds, 5-Hydroxysophoranone (8) exhibited the highest antiplasmodial activity against Plasmodium falciparum (IC50 2.5 microg/mL). Compound 8, erystagallin A (5), erycristagallin (7) and erysubin F (10) showed the same level of antimycobacterial activity against Mycobacterium tuberculosis (MIC 12.5 microg/mL). For cytotoxicity, erybraedin A (2) showed the highest activity against the NCI-H187 and BC cells (IC50 2.1 and 2.9 microg/mL, respectively), whereas 10 exhibited the highest activity against the KB cells (IC50 4.5 microg/mL).
J Ethnopharmacol. 2007 Mar 1;110(1):171-5.
Antibacterial pterocarpans from Erythrina subumbrans.[Pubmed: 17055201 ]

METHODS AND RESULTS:
Seven pterocarpans, erybraedin B (1), erybraedin A (2), phaseollin (3), erythrabyssin II (4), erystagallin A (5), erythrabissin-1 (6) and erycristagallin (7), two flavanones, 5-Hydroxysophoranone (8) and glabrol (9), and one isoflavone, erysubin F (10), were isolated from the stems of Erythrina subumbrans (Leguminosae). Their structures were identified by means of spectroscopy. This is the first report of the isolation of the non-alkaloidal compounds from Erythrina subumbrans and the observed dehydration of 6a-hydroxypterocarpans 5 and 6 in CDCl(3) to the corresponding pterocarpenes 11 and 12, respectively. Compounds 8 and 9 were isolated for the first time from the genus Erythrina. Compounds 2 and 4 exhibited the highest degree of activity against Streptococcus strains with an MIC range of 0.78-1.56 microg/ml, whereas compound 7 exhibited the highest degree of activity against Staphylococcus strains, including drug-resistant strains (MRSA and VRSA), with an MIC range of 0.39-1.56 microg/ml. Interestingly, compounds 2, 4, 5 and 7 were more active against several strains of Streptococcus and Staphylococcus than the standard antibiotics vancomycin and oxacillin. Compound 7 showed the highest level of activity against all VRSA strains tested, with an MIC range of 0.39-1.56 microg/ml, which were resistant to both antibiotics.
CONCLUSIONS:
These compounds may prove to be potent phytochemical agents for antibacterial activity, especially against the MRSA and VRSA strains.
5-Hydroxysophoranone Description
Source: The barks of Erythrina subumbrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
12beta-Acetoxy-3,7,11,15,23-pentao...

Catalog No: CFN95505
CAS No: 1309931-91-6
Price: $318/5mg
2-Cinnamoyl-1-galloylglucose

Catalog No: CFN95098
CAS No: 56994-83-3
Price: $338/5mg
7-(4-Hydroxyphenyl)-1-phenyl-4-hep...

Catalog No: CFN95140
CAS No: 100667-52-5
Price: $318/5mg
Ganoderic acid Df

Catalog No: CFN95514
CAS No: N/A
Price: $318/5mg
Jacquilenin

Catalog No: CFN95434
CAS No: 7726-34-3
Price: $318/5mg
Diosniposide B

Catalog No: CFN95333
CAS No: N/A
Price: $413/5mg
(3S,5S,E)-1,7-Diphenylhept-1-ene-3...

Catalog No: CFN95195
CAS No: 87095-75-8
Price: $318/5mg
1-O-Feruloylglucose

Catalog No: CFN95596
CAS No: 64625-37-2
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0982 mL 10.4908 mL 20.9815 mL 41.963 mL 52.4538 mL
5 mM 0.4196 mL 2.0982 mL 4.1963 mL 8.3926 mL 10.4908 mL
10 mM 0.2098 mL 1.0491 mL 2.0982 mL 4.1963 mL 5.2454 mL
50 mM 0.042 mL 0.2098 mL 0.4196 mL 0.8393 mL 1.0491 mL
100 mM 0.021 mL 0.1049 mL 0.2098 mL 0.4196 mL 0.5245 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Stevenleaf

Catalog No: CFN99189
CAS No: 80321-63-7
Price: $ / mg
Calceolarioside B

Catalog No: CFN90647
CAS No: 105471-98-5
Price: $238/20mg
Parishin C

Catalog No: CFN93114
CAS No: 174972-80-6
Price: $238/20mg
Integerrimine

Catalog No: CFN00419
CAS No: 480-79-5
Price: $ /
Purpurin

Catalog No: CFN92566
CAS No: 81-54-9
Price: $30/20mg
Cyanidin-3-O-(6''-malonylglucoside...

Catalog No: CFN91864
CAS No: 171828-62-9
Price: $613/5mg
Emodin

Catalog No: CFN98834
CAS No: 518-82-1
Price: $30/20mg
Hirsuteine

Catalog No: CFN90615
CAS No: 35467-43-7
Price: $268/5mg
Euphol

Catalog No: CFN89516
CAS No: 514-47-6
Price: $158/10mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Tags: buy 5-Hydroxysophoranone | 5-Hydroxysophoranone supplier | purchase 5-Hydroxysophoranone | 5-Hydroxysophoranone cost | 5-Hydroxysophoranone manufacturer | order 5-Hydroxysophoranone | 5-Hydroxysophoranone distributor