5-Methoxycanthin-6-one | CAS:15071-56-4

5-Methoxycanthin-6-one

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Description:

5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC₅₀ values ranging from 13.5-15.4 uM versus doxorubicine with IC₅₀ = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC₅₀ = 0.9-2.0 uM versus ibuprofen with IC₅₀ = 12.1 uM.

In vitro:

Planta Med. 2012 Dec;78(18):1949-56.

Oxidative burst inhibitory and cytotoxic activity of constituents of the fruits of Odyendyea gabonensis.[Pubmed: 23136063 ]

The methanol extract of dried fruits of Odyendyea gabonensis afforded one new quassinoid [(-)-odyendanol (1)], one new canthin-6-one alkaloid [9-hydroxy-5-Methoxycanthin-6-one (4)], and two new steroids [22E, 24R-stigmasta-5,22-diene-3,7-dione (7) and 22E,24R-stigmast-22-ene-3,7-dione (8)] along with fourteen known compounds.
METHODS AND RESULTS:
The structures of all compounds were established by analyzing the spectroscopic data. The 13C-NMR values of (-)-odyendene (2) and (-)-odyendane (3), as well as the single-crystal X-ray structure of 5-Methoxycanthin-6-one (6) are also reported.The oxidative burst inhibitory activity of pure compounds 1-12 was determined by the chemoluminescence assay, and cytotoxic activities of compounds 2-6 against the human prostate cancer cell PC-3 line were evaluated.
CONCLUSIONS:
Compounds 1-6 exhibited a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC₅₀ = 0.9-2.0 μM versus ibuprofen with IC₅₀ = 12.1 μM, while all canthin-6-one alkaloids (4-6) displayed moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC₅₀ values ranging from 13.5-15.4 μM versus doxorubicine with IC₅₀ = 1.5 μM.

5-Methoxycanthin-6-one Description

Source:	The barks of Ailanthus altissima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nat Prod Res. 2015 Mar 18:1-5.

Harvesting canthinones: identification of the optimal seasonal point of harvest of Zanthoxylum chiloperone leaves as a source of 5-methoxycanthin-6-one.[Pubmed: 25782699 ]

This article is focused on the seasonal variation in the contents of 5-Methoxycanthin-6-one from the leaves of Zanthoxylum chiloperone (Rutaceae).
METHODS AND RESULTS:
Based on the pharmacological interest presented by 5-Methoxycanthin-6-one, its seasonal variation in Z. chiloperone leaves was analysed in order to determine the best time for harvesting, optimising the 5-Methoxycanthin-6-one content. The seasonal dynamics of canthinone alkaloids can be the key to improve the isolation from natural sustainable sources, such as leaves. Complementarily, this study describes the phytochemistry of leaf from this Ruraceae species.

Product Name	5-Methoxycanthin-6-one
Price:
CAS No.:	15071-56-4
Catalog No.:	CFN92362
Molecular Formula:	C₁₅H₁₀N₂O₂
Molecular Weight:	250.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The barks of Ailanthus altissima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Cytotoxic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9952 mL	19.976 mL	39.9521 mL	79.9041 mL	99.8801 mL
5 mM	0.799 mL	3.9952 mL	7.9904 mL	15.9808 mL	19.976 mL
10 mM	0.3995 mL	1.9976 mL	3.9952 mL	7.9904 mL	9.988 mL
50 mM	0.0799 mL	0.3995 mL	0.799 mL	1.5981 mL	1.9976 mL
100 mM	0.04 mL	0.1998 mL	0.3995 mL	0.799 mL	0.9988 mL

CFN92128	4,9-Dimethoxycanthin-6-one	1270001-72-3	280.3	C₁₆H₁₂N₂O₃
CFN92930	5-Hydroxy-canthin-6-one	64118-73-6	236.23	C₁₄H₈N₂O₂
CFN92362	5-Methoxycanthin-6-one	15071-56-4	250.3	C₁₅H₁₀N₂O₂
CFN92205	Picrasidine Q	101219-61-8	266.3	C₁₅H₁₀N₂O₃
CFN99846	5-Hydroxy-4-methoxycanthin-6-one	18110-86-6	266.3	C₁₅H₁₀N₂O₃
CFN99847	4,5-Dimethoxycanthin-6-one	18110-87-7	280.3	C₁₆H₁₂N₂O₃