6-Ethoxydihydrosanguinarine | CAS:28342-31-6

6-Ethoxydihydrosanguinarine

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Product Name	6-Ethoxydihydrosanguinarine
Price:	$268 / 10mg
CAS No.:	28342-31-6
Catalog No.:	CFN89308
Molecular Formula:	C₂₂H₁₉NO₅
Molecular Weight:	377.39 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots and aerial parts of Chelidonium majus L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $98.3 / In-stock
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Description:

6-Ethoxydihydrosanguinarine shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/- 0.19 microM, respectively.

Targets:

AChR | BACE

In vitro:

Nat Prod Commun. 2010 Nov;5(11):1751-4.

Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae).[Pubmed: 21213973]

METHODS AND RESULTS:
The roots and aerial parts of Chelidonium majus L. were extracted with EtOH and fractionated using CHCl3 and EtOH. Repeated column chromatography, preparative TLC and crystallization led to the isolation of five isoquinoline alkaloids, stylopine (3), chelidonine (4), homochelidonine (5), protopine (6), and allocryptopine (7), along with two isolation artifacts 6-Ethoxydihydrosanguinarine (1) and 6-ethoxydihydrochelerythrine (2). All isolated compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity.
CONCLUSIONS:
The isolation artifacts exhibited the highest activity against HuAChE and HuBuChE with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/- 0.19 microM for 6-ethoxydihydrochelerythrine and 3.25 +/- 0.24 microM and 4.51 +/- 0.31 microM for 6-Ethoxydihydrosanguinarine. The most active of the naturally-occurring alkaloids was chelidonine, which inhibited both HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 26.8 +/- 1.2 microM and 31.9 +/- 1.4 microM, respectively.

6-Ethoxydihydrosanguinarine Description

Source:	The roots and aerial parts of Chelidonium majus L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticholinesterase Compound Library Alkaloids Compound Library BACE Inhibitor Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6498 mL	13.2489 mL	26.4978 mL	52.9956 mL	66.2445 mL
5 mM	0.53 mL	2.6498 mL	5.2996 mL	10.5991 mL	13.2489 mL
10 mM	0.265 mL	1.3249 mL	2.6498 mL	5.2996 mL	6.6244 mL
50 mM	0.053 mL	0.265 mL	0.53 mL	1.0599 mL	1.3249 mL
100 mM	0.0265 mL	0.1325 mL	0.265 mL	0.53 mL	0.6624 mL

CFN91002	Oxysanguinarine	548-30-1	347.3	C₂₀H₁₃NO₅
CFN98449	Chelerythrine	34316-15-9	348.4	C₂₁H₁₈NO₄
CFN95373	Bocconoline	32906-88-0	379.4	C₂₂H₂₁NO₅
CFN99367	6-Acetonyl-N-methyl-dihydrodecarine	1253740-09-8	391.4	C₂₃H₂₁NO₅
CFN98233	6-Acetonyldihydrochelerythrine	22864-92-2	405.5	C₂₄H₂₃NO₅
CFN98608	8-Acetonyldihydrosanguinarine	37687-34-6	389.4	C₂₃H₁₉NO₅
CFN92338	8-Acetonyldihydroavicine	348098-59-9	389.4	C₂₃H₁₉NO₅
CFN92339	8-Acetonyldihydronitidine	80330-39-8	405.5	C₂₄H₂₃NO₅
CFN91015	bis[6-(5,6-dihydrochelerythrinyl)]amine	165393-48-6	711.76	C₄₂H₃₇N₃O₈
CFN99749	Acetylcorynoline	18797-80-3	409.43	C₂₃H₂₃NO₆