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6-Hydroxyluteolin 7-glucoside
6-Hydroxyluteolin 7-glucoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 6-Hydroxyluteolin 7-glucoside
Price: $318 / 10mg
CAS No.: 54300-65-1
Catalog No.: CFN91094
Molecular Formula: C21H20O12
Molecular Weight: 464.38 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Saluia plebeia
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $206.7 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
J Agric Food Chem. 2018 Feb 7;66(5):1167-1174.
Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract.[Pubmed: 29345918 ]
The potential use of Origanum majorana L. as a source of bioavailable phenolic compounds, specifically rosmarinic acid (RA), has been evaluated.
METHODS AND RESULTS:
Phenolic bioavailability was tested using an in vitro digestion process followed by a Caco-2 cellular model of intestinal absorption. The HPLC-PAD-MS/MS analysis showed the main components in the extract were 6-hydroxyluteolin-7-O-glucoside(6-Hydroxyluteolin 7-glucoside ) and rosmarinic acid, followed by luteolin-O-glucoside. After digestion process, the amount of total phenolic compounds (TPC) only decreased slightly, although a remarkable reduction in RA (near 50%) was detected. Bioavailable fraction contained 7.37±1.39 mg/L digested extract of RA with small quantities of lithospermic acid and diosmin and presented an important antioxidant activity (0.89±0.09 mmol Trolox/L digested extract). Besides, this bioavailable fraction produced a significant inhibition in TNF-α, IL-1β and IL-6 secretion, using a human THP-1 macrophages model.
CONCLUSIONS:
Therefore, RA content in the basolateral compartment could play an important role in the antioxidant and anti-inflammatory activities found.
6-Hydroxyluteolin 7-glucoside Description
Source: The herbs of Saluia plebeia
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1534 mL 10.767 mL 21.5341 mL 43.0682 mL 53.8352 mL
5 mM 0.4307 mL 2.1534 mL 4.3068 mL 8.6136 mL 10.767 mL
10 mM 0.2153 mL 1.0767 mL 2.1534 mL 4.3068 mL 5.3835 mL
50 mM 0.0431 mL 0.2153 mL 0.4307 mL 0.8614 mL 1.0767 mL
100 mM 0.0215 mL 0.1077 mL 0.2153 mL 0.4307 mL 0.5384 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry, 1980, 19(8):1761-1766.
New 6-hydroxyflavonoids and their methyl ethers and glycosides from Neurolaena oaxacana.[Reference: WebLink]
Six new and nine known flavonoids were obtained from Neurolaena oaxacana.
METHODS AND RESULTS:
The known flavonoids are 6-hydroxykaempferol 3,7-dimethyl ether, quercetagetin 3,7-dimethyl ether, quercetin 3-methyl ether, axillarin, nodifloretin, 6-Hydroxyluteolin 7-glucoside, kaempferol 3-glucoside, quercetagetin 7-glucoside and patulitrin. The new compounds are 6-hydroxykaempferol 3-methyl ether, quercetagetin 3,7-dimethyl ether 6-galactoside, quercetagetin 3-methyl ether 7-glucoside, the 6- and 7-glucosides of 6-hydroxykaempferol 3-methyl ether and quercetagetin 3-methyl ether 7-sulfate.
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