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    6alpha-Hydroxypolyporenic acid C
    Information
    CAS No. 24513-63-1 Price $556 / 10mg
    Catalog No.CFN92741Purity>=98%
    Molecular Weight498.7Type of CompoundTriterpenoids
    FormulaC31H46O5Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    6alpha-Hydroxypolyporenic acid C Description
    Source: The roots of Wolfiporia cocos (Schw.) Ryv.
    Biological Activity or Inhibitors:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0052 mL 10.0261 mL 20.0521 mL 40.1043 mL 50.1303 mL
    5 mM 0.401 mL 2.0052 mL 4.0104 mL 8.0209 mL 10.0261 mL
    10 mM 0.2005 mL 1.0026 mL 2.0052 mL 4.0104 mL 5.013 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8021 mL 1.0026 mL
    100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    6alpha-Hydroxypolyporenic acid C References Information
    Citation [1]

    Zhongguo Zhong Yao Za Zhi. 2008 Jul;33(13):1596-601.

    Absorption of triterpenoid compounds from Indian bread (Poria cocos) across human intestinal epithelial (Caco-2) cells in vitro.[Pubmed: 18837324]
    OBJECTIVE: To study the absorption of 3-epidehydrotumulosic acid (EDHTA), polyporenic acid C (PPAC) and 6alpha-Hydroxypolyporenic acid C (HPPA) isolated from the sclerotium of Poria cocos. In human intestinal epithelial. METHOD: By using Caco-2 (the human colonic adenocarcinoma cell lines) cells monolayer as an intestinal epithelial cell model, the permeability of EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C were studied from apical side (AP side) to basolateral side (BL side) or from BL side to AP side.The P(app) values of EDHTA and PPAC were at a nearly same magnitude with those of propranolol, and 6alpha-Hydroxypolyporenic acid C lied between those of propranolol and atenolol. On the other hand, the efflux transport of EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C were higher 1.78, 1.91 and 2. 47 times more than its influx transport with 0.56, 0.52 and 0.41 rate of P(app A --> B)/P(app (B --> A). CONCLUSION: EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells, among EDHTA and PPAC will be completely. 6alpha-Hydroxypolyporenic acid C will be moderately absorbed compounds. EDHTA, PPAC and 6alpha-Hydroxypolyporenic acid C may have been involved in efflux mechanism in Caco-2 cells monolayers model from the basolateral-to-apical direction.