Science | Nature | Cell | View More
Natural Products
7,4'-Di-O-methylapigenin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 7,4'-Di-O-methylapigenin
Price:
CAS No.: 5128-44-9
Catalog No.: CFN98819
Molecular Formula: C17H14O5
Molecular Weight: 298.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Aquilaria sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Toronto (Canada)
  • Funda??o Universitária de Dese... (Brazil)
  • University of Sao Paulo (Brazil)
  • Universite Libre de Bruxelles (Belgium)
  • Leibniz Institute of Plant Bioc... (Germany)
  • University of Malaya (Malaysia)
  • Aarhus University (Denmark)
  • University of Zurich (Switzerland)
  • Harvard University (USA)
  • University of Wisconsin-Madison (USA)
  • Texas A&M University (USA)
  • More...
Package
Featured Products
Inotodiol

Catalog No: CFN92367
CAS No: 35963-37-2
Price: $338/5mg
Lanosterol

Catalog No: CFN92368
CAS No: 79-63-0
Price: $198/20mg
Licoricidin

Catalog No: CFN96389
CAS No: 30508-27-1
Price: $388/5mg
Adenosine

Catalog No: CFN98992
CAS No: 58-61-7
Price: $30/20mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
Harzianic acid

Catalog No: CFN00118
CAS No: 157148-06-6
Price: $ /
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
Paclitaxel

Catalog No: CFN97759
CAS No: 33069-62-4
Price: $30/20mg
Estragole

Catalog No: CFN70065
CAS No: 140-67-0
Price: $30/20mg
Narirutin

Catalog No: CFN99543
CAS No: 14259-46-2
Price: $80/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Apigenin 7, 4'-dimethyl ether (7,4'-Di-O-methylapigenin) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.
In vitro:
J. Food Sci.Technol., 2015, 52(6):3561-70.
Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4'-dimethyl ether isolated from Piper longum L.[Pubmed: 26028738 ]

METHODS AND RESULTS:
Presence of apigenin 7, 4'-dimethyl ether(7,4'-Di-O-methylapigenin,ADE) and piperine (Pip) in EAP was determined by HPTLC analysis and was isolated. ADE inhibited α-glucosidase and α-amylase enzymes and enhanced 2-NBDG uptake in L6 cells. Hypolipidemic effect of ADE on mouse pre-adipocyte (3T3L1) cell lines also showed a dose dependent reduction on lipid droplet content and effective concentration range was determined as 1-2.5 μg/mL.
CONCLUSIONS:
The results suggested that Piper longum fruits can provide a natural source of antioxidants with antidiabetic and anti obesity potential.
7,4'-Di-O-methylapigenin Description
Source: The herbs of Aquilaria sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3'-Hydroxy-5,7,4'-trimethoxyflavon...

Catalog No: CFN95396
CAS No: 33554-52-8
Price: $318/5mg
Arjungenin

Catalog No: CFN95039
CAS No: 58880-25-4
Price: $318/20mg
Apigenin-8-C-beta-D-glucopyranosyl...

Catalog No: CFN95548
CAS No: N/A
Price: $368/5mg
Gypenoside XIII

Catalog No: CFN95239
CAS No: 80325-22-0
Price: $288/10mg
3-O-Methylellagic acid 3'-O-alpha-...

Catalog No: CFN95375
CAS No: 352280-34-3
Price: $413/5mg
Oblongaroside B

Catalog No: CFN95543
CAS No: 1000889-11-1
Price: $318/10mg
Scoparin

Catalog No: CFN95544
CAS No: 301-16-6
Price: $318/5mg
(1,5E,11E)-tridecatriene-7,9-diyne...

Catalog No: CFN95161
CAS No: 201012-14-8
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3523 mL 16.7616 mL 33.5233 mL 67.0466 mL 83.8082 mL
5 mM 0.6705 mL 3.3523 mL 6.7047 mL 13.4093 mL 16.7616 mL
10 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
50 mM 0.067 mL 0.3352 mL 0.6705 mL 1.3409 mL 1.6762 mL
100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 1999 Feb;62(2):241-3.
Five new flavone 5-O-glycosides from Lethedon tannaensis: lethedosides and lethediosides.[Pubmed: 10075750]

METHODS AND RESULTS:
Five new 7-methoxy-flavone 5-O-glycosides were isolated from a cytotoxic MeOH extract of Lethedon tannaensis, and the structures were elucidated by 2D NMR spectral analysis and by chemical methods. Lethedosides A (1), B (2), and C (3) were 5-O-glucosides of 7,3', 4'-tri-O-methylluteolin, 7,3',4',5'-tetra-O-methyltricetin, and 7,3', 4'-tri-O-methytricetin, respectively; lethediosides A (4) and B (5) and a known compound 6 were 5-O-xylosylglucosides of 7,3', 4'-tri-O-methylluteolin, 7,3',4',5'-tetra-O-methyltricetin, and 7,4'-Di-O-methylapigenin, respectively.
CONCLUSIONS:
These flavonoids were either inactive or weakly active against KB tumor cells, in contrast to previously isolated flavones from the same plant.
Inotodiol

Catalog No: CFN92367
CAS No: 35963-37-2
Price: $338/5mg
Lanosterol

Catalog No: CFN92368
CAS No: 79-63-0
Price: $198/20mg
Licoricidin

Catalog No: CFN96389
CAS No: 30508-27-1
Price: $388/5mg
Adenosine

Catalog No: CFN98992
CAS No: 58-61-7
Price: $30/20mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
Harzianic acid

Catalog No: CFN00118
CAS No: 157148-06-6
Price: $ /
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
Paclitaxel

Catalog No: CFN97759
CAS No: 33069-62-4
Price: $30/20mg
Estragole

Catalog No: CFN70065
CAS No: 140-67-0
Price: $30/20mg
Narirutin

Catalog No: CFN99543
CAS No: 14259-46-2
Price: $80/20mg
Tags: buy 7,4'-Di-O-methylapigenin | 7,4'-Di-O-methylapigenin supplier | purchase 7,4'-Di-O-methylapigenin | 7,4'-Di-O-methylapigenin cost | 7,4'-Di-O-methylapigenin manufacturer | order 7,4'-Di-O-methylapigenin | 7,4'-Di-O-methylapigenin distributor