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7-Hydroxyflavanone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 7-Hydroxyflavanone
Price: $50 / 20mg
CAS No.: 6515-36-2
Catalog No.: CFN94487
Molecular Formula: C15H12O3
Molecular Weight: 240.26 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The stems of Spatholobus suberectus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $14.8 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates, it could be useful for the development of a novel respiratory infections treatment.
Targets: Antifection
In vitro:
Phytother Res. 2011 Apr;25(4):615-8.
20S proteasome inhibitory activity of flavonoids isolated from Spatholobus suberectus.[Pubmed: 21104764 ]
The promising biological role of the ubiquitin proteasome pathway (UPP) in cancer therapy has recently emerged.
METHODS AND RESULTS:
Inhibition of proteasome has been proposed as a new therapeutic target for treatment of cancer. Bioassay-guided fractionation of a MeOH extract of the stems of Spatholobus suberectus resulted in seven compounds, liquiritigenin (1), isoliquiritigenin (2), genistein (3), daidzein (4), medicarpin (5), 7-Hydroxyflavanone (6) and formononetin (7), which were evaluated for the first time for their inhibitory effect on 20S proteasome. Among the isolated compounds, 2, 3 and 6 exhibited inhibitory activities on human 20S proteasome with IC(50) values of 4.88 ± 1.5, 9.26 ± 1.2 and 5.21 ± 1.5 μm, respectively.
In vivo:
J Ethnopharmacol. 2012 Mar 27;140(2):287-92.
Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: in vitro and in vivo studies.[Pubmed: 22285202 ]
Zuccagnia punctata Cav. (Fabaceae) is a monotypic species distributed in western Argentina and is traditionally used for the treatment of bacterial and fungal infections.
METHODS AND RESULTS:
The aim of this study was to demonstrated the antibacterial activity of the Zuccagnia punctata standardized extract and the structurally related non-methoxylated flavonoids with similar pattern of substitution and differences in ring C present in this plant species: 7-Hydroxyflavanone (HF), 2',4'-dihydroxychalcone (DHC) and 3,7-dihydroxyflavone (DHF), against Streptococcus pneumoniae clinical isolates using in vitro and in vivo models.All samples showed antimicrobial activity in vitro with MIC values between 50 and 500μg/ml. Zuccagnia punctata extract (1mg/mice) and HF (1mg/mice) significantly reduced the number of viable Streptococcus pneumoniae in lung (p<0.01) while lower quantities has not effect. Therefore, the present study has shown that intake once or twice a day of 1mg of Zuccagnia punctata extract or HF for seven days did not result in toxicity.
CONCLUSIONS:
Our results showed that Zuccagnia punctata extract as well as one of its isolated flavonoids, 7-Hydroxyflavanone, could be useful for the development of a novel respiratory infections treatment.
7-Hydroxyflavanone Description
Source: The stems of Spatholobus suberectus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1622 mL 20.8108 mL 41.6216 mL 83.2432 mL 104.0539 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL 16.6486 mL 20.8108 mL
10 mM 0.4162 mL 2.0811 mL 4.1622 mL 8.3243 mL 10.4054 mL
50 mM 0.0832 mL 0.4162 mL 0.8324 mL 1.6649 mL 2.0811 mL
100 mM 0.0416 mL 0.2081 mL 0.4162 mL 0.8324 mL 1.0405 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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