Albanin A | CAS:73343-42-7 | Manufacturer ChemFaces

Albanin A

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Description:

Albanin A shows mushroom tyrosinase inhibitory activity, the IC50 value is 463 uM.

Targets:

Tyrosinase

In vitro:

Letters in Drug Design & Discovery, 2010 , 7 (8) :602-605.

Melanin Biosynthesis Inhibitors from Wood of Artocarpus heterophyllus: The Effect of Isoprenoid Substituent of Flavone with 4-Substituted Resorcinol Moiety at B Ring[Reference: WebLink]

In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity.
METHODS AND RESULTS:
By activity-guided fractionation of A. heterophyllus wood extract, norartocarpetin (1) and artocarpesin (2) were isolated. These compounds have 4-substituted resorcinol moiety in B ring, which is an important substructure for revealing the tyrosinase inhibitory activity. Also, the effect of Albanin A (3) which has 4-substituted resorcinol moiety at B ring with prenyl substituent at C-3 position, was examined for comparison.
CONCLUSIONS:
The IC50 values of mushroom tyrosinase inhibitory activity of norartocarpetin (1), artocarpesin (2) and Albanin A (3) were 1.7, 8.5 and 463 μM, respectively. In melanin formation inhibition on B16 melanoma cells, the IC50 of these compounds (1-3) were 209.1, 45.1 and 40.1 μM, respectively. The roles of each substructure of flavones having 4-substituted resorcinol moiety with or without prenyl substituent on tyrosinase and melanin biosynthesis in B16 melanoma cells were discussed.

Albanin A Description

Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Albanin A
Price:
CAS No.:	73343-42-7
Catalog No.:	CFN92325
Molecular Formula:	C₂₀H₁₈O₆
Molecular Weight:	354.4 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-melanogenic Compound Library Flavonoids Compound Library Tyrosinase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8217 mL	14.1084 mL	28.2167 mL	56.4334 mL	70.5418 mL
5 mM	0.5643 mL	2.8217 mL	5.6433 mL	11.2867 mL	14.1084 mL
10 mM	0.2822 mL	1.4108 mL	2.8217 mL	5.6433 mL	7.0542 mL
50 mM	0.0564 mL	0.2822 mL	0.5643 mL	1.1287 mL	1.4108 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.5643 mL	0.7054 mL

CFN92322	5,7,2',4'-Tetrahydroxy-3-geranylflavone	376361-87-4	422.5	C₂₅H₂₆O₆
CFN97085	Mulberrin	62949-79-5	422.5	C₂₅H₂₆O₆
CFN97083	Morusin	62596-29-6	420.5	C₂₅H₂₄O₆
CFN97086	Morusinol	62949-93-3	438.5	C₂₅H₂₆O₇
CFN97581	8-Isomulberrin hydrate	N/A	440.5	C₂₅H₂₈O₇
CFN97239	Artocarpin	7608-44-8	436.5	C₂₆H₂₈O₆
CFN97892	3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone	1334309-44-2	490.6	C₃₀H₃₄O₆
CFN90834	Kuwanon A	62949-77-3	420.5	C₂₅H₂₄O₆
CFN92416	Sanggenone K	86450-77-3	488.6	C₃₀H₃₂O₆
CFN93278	Kuwanon G	75629-19-5	692.71	C₄₀H₃₆O₁₁