Science | Nature | Cell | View More
Natural Products
Alismol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Alismol
Price: $318 / 10mg
CAS No.: 87827-55-2
Catalog No.: CFN97446
Molecular Formula: C15H24O
Molecular Weight: 220.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The tubers of Alisma plantago-aquatica Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $144.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Sanford Burnham Medical Researc... (USA)
  • Melbourne University (Australia)
  • Northeast Normal University Cha... (China)
  • Michigan State University (USA)
  • University of Hertfordshire (United Kingdom)
  • Johannes Gutenberg University M... (Germany)
  • The Ohio State University (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • Ateneo de Manila University (Philippines)
  • Monash University (Australia)
  • Universidade Católica Portuguesa (Portugal)
  • More...
Package
Featured Products
Pseudoprotodioscin

Catalog No: CFN90694
CAS No: 102115-79-7
Price: $138/20mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Europine

Catalog No: CFN00264
CAS No: 570-19-4
Price: $ /
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /
2'-Acetylacteoside

Catalog No: CFN92452
CAS No: 94492-24-7
Price: $188/20mg
Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg
Liensinine

Catalog No: CFN99580
CAS No: 2586-96-1
Price: $100/20mg
Tanshinone I

Catalog No: CFN98953
CAS No: 568-73-0
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. Alismol has inhibitory effect to MMP3 expression and nitric oxide produced in microglial cells. It holds great promise for use in chemopreventive and chemotherapeutic strategies.
Targets: Calcium Channel | Potassium Channel | PI3K | Akt | ERK | JNK | Caspase | MMP(e.g.TIMP)
In vitro:
Jpn J Pharmacol. 1988 Apr;46(4):331-5.
Effect of alismol on adrenergic mechanism in isolated rabbit ear artery.[Pubmed: 3404764 ]
Effects of Alismol, a sesquiterpenoid isolated from the rhyzome of Alisma orientale, on adrenergic mechanisms were examined in the isolated rabbit ear artery.
METHODS AND RESULTS:
Alismol (10(-6) to 10(-4) M) inhibited the contraction of isolated rabbit ear artery by electrical stimulation of the perivascular nerves. The inhibition was concentration-dependent; at a concentration of 10(-4) M, the inhibition was 90% (n = 8). Treatment with 10(-4) M Alismol inhibited the increase in 3H-noradrenaline (3H-NAd) release induced by electrical stimulation by 63 +/- 6%. Alismol at 10(-4) M did not affect the neuronal uptake of 3H-NAd in the artery. Alismol at 10(-4) M slightly inhibited contractions induced by exogenously administered NAd.
CONCLUSIONS:
These results demonstrate that Alismol inhibits the adrenergic neuro-effector mechanisms in rabbit ear artery, and they suggest that Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release.
Life Sci. 1987 Oct 12;41(15):1845-52.
Effects of alismol isolated from Alismatis Rhizoma on calcium-induced contraction in the rabbit thoracic aorta.[Pubmed: 3657386]

METHODS AND RESULTS:
We examined the inhibitory effects of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, on vascular contractions induced by high concentrations of K+ and Ca2+, and on 45Ca2+ retention in normal and in high K+-containing medium. Alismol affected neither the resting tension nor the 45Ca2+ retention in normal medium, but it inhibited sustained contraction and increased 45Ca2+ retention induced by high K+ concentrations. Alismol did not affect norepinephrine-induced contractions in normal medium, nor phasic contractions in Ca2+-free medium.
CONCLUSIONS:
These results suggested that Alismol inhibited mainly Ca2+ influx through a voltage-dependent Ca2+ channel.
Phytother. Res., 1989, 3(2):72-4.
Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat.[Reference: WebLink]

METHODS AND RESULTS:
The effect of Alismol (Oshima et al., 1983), a sesquiterpenoid isolated from Alismatis Rhizoma which is used as a Chinese crude drug, was studied on rat isolated heart using the working heart perfusion technique. Alismol decreased cardiac output, heart rate and left ventricular pressure, but it increased coronary flow.
CONCLUSIONS:
The drug has been used for the prevention of anginal attacks and our results provide a pharmacological basis for one of the traditional medicinal effects of Alismatis Rhizoma.
In vivo:
Phytother. Res., 1989, 3(2):57-60.
The effect of alismol isolated from Alismatis Rhizoma on experimental hypertensive models in rats.[Reference: WebLink]

METHODS AND RESULTS:
The antihypertensive action of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of Alismol on the activation of plasma renin, angiotensin-converting enzyme (ACE) and the level of aldosterone were examined in 2-kidney, 1-clip hypertensive model.
CONCLUSIONS:
Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.
Alismol Description
Source: The tubers of Alisma plantago-aquatica Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Sphenanlignan

Catalog No: CFN95245
CAS No: 866347-36-6
Price: $318/5mg
Annphenone

Catalog No: CFN95426
CAS No: 61775-18-6
Price: $318/10mg
8-epi-Confertin

Catalog No: CFN95509
CAS No: 110115-60-1
Price: $318/5mg
Diosmin Impurity 8

Catalog No: CFN95309
CAS No: 28719-21-3
Price: $318/10mg
Margaritene

Catalog No: CFN95303
CAS No: 64271-10-9
Price: $318/10mg
Lappaol C

Catalog No: CFN95068
CAS No: 64855-00-1
Price: $333/10mg
(R)-Mucronulatol

Catalog No: CFN95492
CAS No: 57128-11-7
Price: $318/10mg
Ganoderenic acid G

Catalog No: CFN95517
CAS No: 120481-73-4
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5372 mL 22.686 mL 45.3721 mL 90.7441 mL 113.4301 mL
5 mM 0.9074 mL 4.5372 mL 9.0744 mL 18.1488 mL 22.686 mL
10 mM 0.4537 mL 2.2686 mL 4.5372 mL 9.0744 mL 11.343 mL
50 mM 0.0907 mL 0.4537 mL 0.9074 mL 1.8149 mL 2.2686 mL
100 mM 0.0454 mL 0.2269 mL 0.4537 mL 0.9074 mL 1.1343 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Experimental Technology & Management, 2012, 29(10):47-50.
Inhibitory effect of alismol to MMP3 expression and nitric oxide produced in microglial cells.[Reference: WebLink]
This paper investigates the inhibitory effect and mechanism of Alismol on neuroinflammation in the activated BV2 microglial cells which are stimulated by lipopolysaccharides(LPS).
METHODS AND RESULTS:
NO was measured by using Griess reagent.RT-PCR and Western blot are used to analyse ERK,JNK,Akt,and MMP3.Alismol can significantly inhibit LPS-induced NO production and the MMP3 expression.The mechanism is involved to its inhibition of PI3K/Akt pathway.
Cell Research:
Evid Based Complement Alternat Med. 2013;2013:257108.
In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria.[Pubmed: 23762112]

METHODS AND RESULTS:
Bioassay-guided isolation of the active hexane fractions of Curcuma zedoaria led to the identification of five pure compounds, namely, curzerenone (1), neocurdione (2), curdione (3), Alismol (4), and zederone (5) and a mixture of sterols, namely, campesterol (6), stigmasterol (7), and β -sitosterol (8). Alismol has never been reported to be present in Curcuma zedoaria. All isolated compounds except (3) were evaluated for their cytotoxic activity against MCF-7, Ca Ski, and HCT-116 cancer cell lines and noncancer human fibroblast cell line (MRC-5) using neutral red cytotoxicity assay. Curzerenone and Alismol significantly inhibited cell proliferation in human cancer cell lines MCF-7, Ca Ski, and HCT-116 in a dose-dependent manner. Cytological observations by an inverted phase contrast microscope and Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with curzerenone and Alismol. Both compounds induce apoptosis through the activation of caspase-3. It can thus be suggested that curzerenone and Alismol are modulated by apoptosis via caspase-3 signalling pathway.
CONCLUSIONS:
The findings of the present study support the use of Curcuma zedoaria rhizomes in traditional medicine for the treatment of cancer-related diseases. Thus, two naturally occurring sesquiterpenoids, curzerenone and Alismol, hold great promise for use in chemopreventive and chemotherapeutic strategies.
Pseudoprotodioscin

Catalog No: CFN90694
CAS No: 102115-79-7
Price: $138/20mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Europine

Catalog No: CFN00264
CAS No: 570-19-4
Price: $ /
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /
2'-Acetylacteoside

Catalog No: CFN92452
CAS No: 94492-24-7
Price: $188/20mg
Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg
Liensinine

Catalog No: CFN99580
CAS No: 2586-96-1
Price: $100/20mg
Tanshinone I

Catalog No: CFN98953
CAS No: 568-73-0
Price: $30/20mg
Tags: buy Alismol | Alismol supplier | purchase Alismol | Alismol cost | Alismol manufacturer | order Alismol | Alismol distributor